{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T18:03:26Z","timestamp":1783361006533,"version":"3.54.6"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare risks of neonatal anomalies and obstetric complications among frozen\u2013thawed embryo transfer (FET), fresh embryo transfer (FreshET), and non\u2010assisted reproductive technology (non\u2010ART) treatments in infertile women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study analyzed 7378 singleton births (2643 non\u2010ART, 4219 FET, 516 FreshET) from 2013 to 2022. Outcomes were compared using inverse probability weighting regression adjustment, with adjustment for maternal factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After adjustment, the risk of neonatal anomalies did not differ significantly between FET and non\u2010ART, or FreshET and non\u2010ART. FET was associated with increased risks of obstetric complications compared with non\u2010ART, including placenta accreta (adjusted risk difference [ARD] 3.61%, 95% CI 2.95\u20134.28), placenta previa (ARD 0.55%, 95% CI 0.14\u20130.96), postpartum hemorrhage (ARD 7.08%, 95% CI 6.03\u20138.13), gestational hypertension (ARD 3.57%, 95% CI 2.47\u20134.68), gestational diabetes (ARD 0.96%, 95% CI 0.17\u20131.75), and preterm birth (ARD 2.13%, 95% CI 1.23\u20133.02). FET also showed higher risk of high birth weight (ARD 0.97%, 95% CI 0.42\u20131.52). FreshET showed no significant differences in obstetric complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While the risk of neonatal anomalies did not differ among treatments, FET was associated with increased obstetric complication risks. These findings underscore the need for careful management of FET pregnancies and further research to improve treatment protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.12623","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T06:31:31Z","timestamp":1737613891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risks of neonatal anomalies and obstetric complications in 7378 singleton births after frozen\u2013thawed and fresh embryo transfers in Japan: An analysis using doubly robust estimation"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1080-0868","authenticated-orcid":false,"given":"Sanae","family":"Terada","sequence":"first","affiliation":[{"name":"Reproductive Medicine Department Okayama Couple's Clinic  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Habara","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Department Okayama Couple's Clinic  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Terada","sequence":"additional","affiliation":[{"name":"Terada Naika Clinic  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiharu","family":"Mitsuhashi","sequence":"additional","affiliation":[{"name":"Okayama University Hospital Center for Innovative Clinical Medicine  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuhei","family":"So","sequence":"additional","affiliation":[{"name":"Okayama Psychiatric Medical Center  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanako","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Department Okayama Couple's Clinic  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Masumoto","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Department Okayama Couple's Clinic  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Kosaka","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Department Okayama Couple's Clinic  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Hirata","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Department Okayama Couple's Clinic  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyoshi","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Department Okayama Couple's Clinic  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15437"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2015.5355"},{"key":"e_1_2_8_4_1","article-title":"Assisted reproductive technology in Japan: a summary report for 2021 by the ethics Committee of the Japan Society of obstetrics and gynecology. 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