{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:07:22Z","timestamp":1790024842358,"version":"4.0.1"},"reference-count":108,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":70,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005026","name":"Stichting Tegen Kanker","doi-asserted-by":"publisher","award":["C69"],"award-info":[{"award-number":["C69"]}],"id":[{"id":"10.13039\/501100005026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007224","name":"National Foundation for Science and Technology Development","doi-asserted-by":"publisher","award":["FWO.106\u2010YS.2017.02"],"award-info":[{"award-number":["FWO.106\u2010YS.2017.02"]}],"id":[{"id":"10.13039\/100007224","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007224","name":"National Foundation for Science and Technology Development","doi-asserted-by":"publisher","award":["Nr GOD97.18N"],"award-info":[{"award-number":["Nr GOD97.18N"]}],"id":[{"id":"10.13039\/100007224","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["Nr G.0343.13"],"award-info":[{"award-number":["Nr G.0343.13"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In vitro oocyte maturation (IVM) is not a novel concept; however, its wide\u2010scale practice has been limited because of the lower clinical outcomes compared to conventional assisted reproductive technologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This comprehensive review addresses the significant advances made in oocyte in\u00a0vitro maturation with the biphasic capacitation (CAPA)\u2010IVM strategy applied to small ovarian antral follicles in humans over the last 10\u2009years. CAPA\u2010IVM consists of a prematuration phase wherein immature oocytes are temporarily meiotically arrested to gain competence before undergoing meiotic resumption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main findings<\/jats:title>\n                    <jats:p>The integration of knowledge from basic research in animal models into clinical practice has led to a reevaluation of IVM for policystic ovary syndrome (PCOS) and onco\u2010fertility patients. The introduction of meticulously conceived growth factors, hormonal supplements, and culture conditions led to an integrated biphasic CAPA\u2010IVM system that promotes oocyte competence. A series of prospective randomized controlled studies validated the reproducible improvements in clinical outcomes and the safety of CAPA\u2010IVM. So far, nearly 1000 babies have been born using this approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of CAPA\u2010IVM in clinical studies has set the tone for major progress in the field and is achieving a safer, less expensive, and less emotionally loaded IVF experience, currently validated for PCOS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.12640","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T06:23:39Z","timestamp":1741760619000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Human oocyte capacitation culture: Essential step toward hormone\u2010free assisted reproductive technology"],"prefix":"10.1002","volume":"24","author":[{"given":"Johan","family":"Smitz","sequence":"first","affiliation":[{"name":"Follicle Biology Laboratory, Faculty of Medicine and Pharmacy Vrije Universiteit Brussel  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1762-6184","authenticated-orcid":false,"given":"Flor","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Centro de Estudios e Investigaciones en Biolog\u00eda y Medicina Reproductiva  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Romero","sequence":"additional","affiliation":[{"name":"Centro de Fertilidad y Reproducci\u00f3n Asistida  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Van Ranst","sequence":"additional","affiliation":[{"name":"Follicle Biology Laboratory, Faculty of Medicine and Pharmacy Vrije Universiteit Brussel  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Anckaert","sequence":"additional","affiliation":[{"name":"Follicle Biology Laboratory, Faculty of Medicine and Pharmacy Vrije Universiteit Brussel  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Gilchrist","sequence":"additional","affiliation":[{"name":"Fertility &amp; Research Centre, Discipline of Women's Health, School of Clinical Medicine University of New South Wales Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuong M.","family":"Ho","sequence":"additional","affiliation":[{"name":"IVFMD My Duc Hospital  Ho Chi Minh City Viet Nam"},{"name":"HOPE Research Center  Ho Chi Minh City Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan N.","family":"Vuong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Medicine and Pharmacy at Ho Chi Minh City  Ho Chi Minh City Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2834-2726","authenticated-orcid":false,"given":"Yoshiharu","family":"Morimoto","sequence":"additional","affiliation":[{"name":"HORAC Grand Front Osaka Clinic  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-011-9554-4"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.113.110577"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.114.118869"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-22-0277"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.111.092858"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-17-2-121"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-015-1129-2_5"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1472\u20106483(10)60168\u2010x"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmq014"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-018-0445-5"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/4.2.103"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1220481"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.suppl_3.52"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.4.747"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1220587"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)62160-8"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1427"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00376"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.07.1108"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu248"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-019-01677-6"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2024.09.010"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-021-02118-z"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex262"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-019-01551-5"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab237"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1080310111"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod56.1.238"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2795(199908)53:4<451::AID-MRD11>3.0.CO;2-3"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57377-4"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem178"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-022-02602-0"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0390053"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev083"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gas038"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00780"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead024"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-015-0010-7"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.03.015"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmad023"},{"issue":"11","key":"e_1_2_13_42_1","article-title":"Human chorionic gonadotrophin priming for fertility treatment with in\u00a0vitro maturation","volume":"11","author":"Reavey J","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-62-2-305"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a136365"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-56-5-1022"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa240"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-013-0006-1"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.116.139808"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9437"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193573"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.035238"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.109.077768"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-019-01610-x"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gax032"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1118"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.20128"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1727"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq212"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des158"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gat028"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.22307"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq290"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem140"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.671487"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.013050"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-020-01724-7"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-021-02382-z"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.01.027"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani13060980"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaaf001"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2024.06.030"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew020"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioab176"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.015982"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem344"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.105.040485"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaq031"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.11.027"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm040"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa043"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.02.010"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2023.09.004"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12587"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-23-0191"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioae125"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-09-0230"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-8-97"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2010.09.012"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-08238-5"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez086"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.07.001"},{"issue":"5","key":"e_1_2_13_92_1","article-title":"Aromatase inhibitors (letrozole) for subfertile women with polycystic ovary syndrome","volume":"5","author":"Franik S","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j138"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey256"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der401"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.01.011"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.09.022"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.04.046"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.055"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-016-0263-6"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-018-1317-z"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-021-02355-2"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-024-03234-2"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu155"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-03080-1"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu329"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez121"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deac115"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-022-02559-0"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12640","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rmb2.12640","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T08:56:45Z","timestamp":1769590605000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmb2.12640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":108,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/rmb2.12640"],"URL":"https:\/\/doi.org\/10.1002\/rmb2.12640","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12640"}}