{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:33:42Z","timestamp":1769636022092,"version":"3.49.0"},"reference-count":71,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":111,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["24ZR1444200"],"award-info":[{"award-number":["24ZR1444200"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871199"],"award-info":[{"award-number":["81871199"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2705503"],"award-info":[{"award-number":["2023YFC2705503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This pilot study aimed to explore the necessity for 47,XYY syndrome males (couples) to perform PGT rather than conventional In\u00a0Vitro Fertilization (IVF)\/Intracytoplasmic Sperm Injection (ICSI) cycles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted with 36 nonmosaic and mosaic 47,XYY syndrome patients (couples) undergoing 43 oocyte retrieval cycles (37 planned for PGT and 6 for IVF\/ICSI) between December 2017 and December 2023. The couples were given either next\u2010generation sequencing\u2010based PGT or conventional IVF\/ICSI followed by 45 embryo transfer (ET) cycles (38 from PGT and 7 from IVF\/ICSI). The detailed cytogenetic results of the 129 embryos from PGT were analyzed, and the pregnancy and neonatal outcomes between PGT\u2010ET and conventional IVF\/ICSI\u2010ET cycles were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The PGT results showed that the chance of sex chromosome abnormalities was low (1.55%), with chromosomal errors being observed more often in autosomes. Importantly, no differences were observed in the rates of biochemical pregnancy, implantation, clinical pregnancy, ongoing pregnancy, pregnancy loss, live birth, and preterm delivery between PGT\u2010ET cycles and conventional IVF\/ICSI\u2010ET cycles. Comparable results regarding gestational age, birthweight, low birthweight rate, macrosomia rate, male rate, as well as the rate of congenital anomalies were also observed between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preimplantation genetic testing might not be necessary to conduct for 47,XYY syndrome males unless there are other indications. Studies with large populations are in demand to confirm the present results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.12650","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T03:02:22Z","timestamp":1745550142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preimplantation genetic testing might not be the necessity for male patients with 47,XYY syndrome: A pilot study"],"prefix":"10.1002","volume":"24","author":[{"given":"Fan","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si\u2010Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1897-3217","authenticated-orcid":false,"given":"Xiang\u2010Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai China"},{"name":"Shanghai Human Sperm Bank, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8343-5178","authenticated-orcid":false,"given":"Ping","family":"Ping","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbir.1996.0002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-017-1793-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12875"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebcr.2014.02.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-15"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2010.07.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC\u201022\u20100440"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086893"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-1626-2-28"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem377"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13039-016-0218-z"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del051"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/14647273.2017.1353143"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019375"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.12.020"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.1295"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366\u20106999.237393"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0223(200012)20:13<1063::AID-PD982>3.0.CO;2-F"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.05.061"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11070724"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/jhrs.JHRS_132_18"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoaa017"},{"issue":"4","key":"e_1_2_8_24_1","first-page":"188","article-title":"47,XYY syndrome and male infertility","volume":"15","author":"Kim IW","year":"2013","journal-title":"Rev Urol"},{"key":"e_1_2_8_25_1","volume-title":"WHO Laboratory manual for the examination and processing of human semen","author":"World Health Organization","year":"2010"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deae068"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/aja.aja_30_21"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57853-4"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57913-8"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2021.05.020"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00518-5"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.10.054"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-023-01301-3"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-022-02654-2"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-23-0011"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13591"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1500421"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.10.019"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.5302"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.04.013"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-022-00935-0"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1705334"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.03.001"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoad046"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.123.2.219"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199704)17:4<363::AID-PD79>3.0.CO;2-O"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011\u20100719"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-4388.165719"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1159\/000500799"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.129.6.564"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.05.037"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)31859\u20106"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00293597"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2010.01129.x"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn017"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1994.tb02455.x"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1978.tb02205.x"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12352"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12081911"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2103613"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.07.1346"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deac191"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2022.10.010"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13415"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2022.03.013"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab177"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2020.05.005"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2019.875"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.01.011"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu016"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh077"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deac152"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12650","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rmb2.12650","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T08:54:22Z","timestamp":1769590462000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmb2.12650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/rmb2.12650"],"URL":"https:\/\/doi.org\/10.1002\/rmb2.12650","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12650"}}