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Testiculopathy disrupts spermatogenesis and the sperm microenvironment, with the cyclic adenosine monophosphate (cAMP) response element modulator (CREM) playing a pivotal role in testicular function. Understanding the interplay between T2D and CREM dysregulation is essential for developing targeted therapies for diabetic testicular dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review of PubMed, Web of Science, Scopus, and Google Scholar was conducted to identify peer\u2010reviewed studies, both preclinical and clinical, that explored CREM's role in diabetes\u2010induced testicular dysfunction. Extracted data focused on CREM expression, oxidative stress, apoptosis, and spermatogenic impairment in diabetic models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Findings<\/jats:title>\n                    <jats:p>Research from studies on diabetic patients and animal models highlights the detrimental effects of diabetes on the reproductive system, including hypothalamic\u2013pituitary\u2013testicular (HPT) axis dysregulation. CREM regulates spermatogenic gene expression, influenced by luteinizing hormone (LH), follicle\u2010stimulating hormone (FSH), and cAMP signaling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CREM has a therapeutic role in maintaining testicular function, and its disruption may contribute to testiculopathy in T2D, highlighting its potential therapeutic target for preserving male fertility in diabetic patients. Further research is needed to explore its molecular mechanisms and therapeutic implications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.12661","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T03:54:05Z","timestamp":1749095645000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Potential Role of\n                    <scp>CREM<\/scp>\n                    in Diabetes\u2010Associated Testicular Dysfunction: Current Evidence and Future Perspectives"],"prefix":"10.1002","volume":"24","author":[{"given":"Olabimpe Caroline","family":"Badejogbin","sequence":"first","affiliation":[{"name":"Department of Physiology College of Basic Medical Sciences, Babcock University  Ilishan\u2010Remo Ogun State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyedayo Phillips","family":"Akano","sequence":"additional","affiliation":[{"name":"Department of 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