{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T20:58:54Z","timestamp":1769633934063,"version":"3.49.0"},"reference-count":77,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":210,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This systematic review aimed to evaluate whether specific single nucleotide polymorphisms (SNPs) in miRNAs are associated with recurrent implantation failure (RIF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted across PubMed\u2010MEDLINE, Web of Science, Scopus, and the Excerpta Medica DataBASE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Newcastle\u2010Ottawa Scale (NOS)\u00a0yielded an intermediate to high quality, with one study rated with 6 stars, and the remaining four with 7 stars. RIF risk\u2010related genotypes included miR\u2010196a, miR\u2010449b, miR\u201034a, miR\u2010146aCG+GG\u2010miR\u2010196a2CC, miR\u2010149TT\u2010miR\u2010196a2CC, miR\u2010196a2CC\u2010miR\u2010499AA, miR\u2010608GC\u2010miR\u2010938CC, miR\u201027aAG\u2010miR\u2010423CC\/miR\u2010604AG\/GG and miR\u201034aC&gt;A AA\u2010miR\u2010130aG&gt;A GG. Protective combinations included miR\u20101302\u20103, miR\u2010631II\u2010miR\u20101302\u20103CT, and miR\u2010938CC\u2010miR\u20101302\u20103CT. Protective allele combinations G\u2010T\u2010T\u2010A, C\u2010T, T\u2010T\u2010G, T\u2010T and G\u2010C\u2010A\u2010G, G\u2010A\u2010G, A\u2010G\u2010G were less frequent in RIF cases, whereas A\u2010T\u2010C, T\u2010C\u2010C\u2010T, T\u2010C\u2010T, A\u2010C\u2010G\u2010A, A\u2010A\u2010G\u2010G, G\u2010A\u2010A\u2010A, A\u2010A\u2010C\u2010A and G\u2010G\u2010A haplotypes were more commonly associated with increased risk. Notably, miR\u2010608 GC+CC, miR\u20101302\u20103 CC, miR\u201027a AG+GG, miR\u2010423 CA+AA, miR\u2010604 AG+GG, miR\u2010222 GT+TT, and miR\u201034a GA+AA were associated with altered coagulation parameters. Additionally, miR\u2010222 correlated with decreased creatinine levels, the G&gt;T mutation with elevated follicle\u2010stimulating hormone (FSH), miR\u201034aC&gt;A AA genotype with reduced thyroid\u2010stimulating hormone (TSH) levels, and CA+AA with increased blood urea nitrogen (BUN) levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This systematic review highlights that specific miRNA SNPs and haplotype combinations are significantly associated with either increased susceptibility to or protection against RIF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.12670","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T19:40:23Z","timestamp":1753904423000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Systematic Evidence\u2010Based Review Regarding miRNA Polymorphisms in Recurrent Implantation Failure"],"prefix":"10.1002","volume":"24","author":[{"given":"Bogdan","family":"Doroftei","sequence":"first","affiliation":[{"name":"Department of Mother and Child, Faculty of Medicine University of Medicine and Pharmacy \u201cGrigore T. 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