{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T20:52:16Z","timestamp":1769633536389,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":218,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine & Biology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n In in\u00a0vitro fertilization (IVF), transferring frozen\u2013thawed blastocysts is a widely adopted practice. This meta\u2010analysis aims to evaluate the reproductive outcomes of transferring blastocysts derived from frozen\u2013thawed cleavage embryos (FT\u2010CDB group) compared to direct frozen\u2013thawed blastocyst (DFB group) transfers.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We searched the following electronic databases for relevant studies: PubMed\/MEDLINE, EMBASE, Scopus, and Web of Science. Studies were included if they compared the clinical and neonatal outcomes of IVF patients receiving either FT\u2010CDB or DFB transfer with vitrification method. The protocol for this review has been registered in PROSPERO.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of seven studies (2057 patients) were included in the analysis. Participants in the FT\u2010CDB group demonstrated significantly higher odds of achieving clinical pregnancy (OR 1.24, 95% CI 1.03\u20131.49,\n p<\/jats:italic>\n \u2009=\u20090.022,\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u200927%), and live birth (OR 1.31, 95% CI 1.08\u20131.60,\n p<\/jats:italic>\n \u2009=\u20090.007,\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20090%) compared to the DFB group. No significant differences were observed in the birth weights of infants between the groups (MD \u221287.05\u2009g, 95% CI \u2212293.77 to 119.67,\n p<\/jats:italic>\n \u2009=\u20090.41,\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u200983%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Transferring blastocysts derived from frozen\u2013thawed cleavage embryos is associated with higher odds of clinical pregnancy and live birth compared to frozen\u2013thawed blastocyst transfers.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n PROSPERO number: CRD42024591620<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/rmb2.12673","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T09:21:51Z","timestamp":1754558511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reproductive Outcomes of Transferring Blastocysts Derived From Frozen\u2013Thawed Cleavage Embryos: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8737-5208","authenticated-orcid":false,"given":"Huy Phuong","family":"Tran","sequence":"first","affiliation":[{"name":"Faculty of Biology and Biotechnology University of Science Ho Chi Minh City Vietnam"},{"name":"Laboratory of Tissue Engineering and Biomedical Materials University of Science Ho Chi Minh City Vietnam"},{"name":"Vietnam National University Ho Chi Minh City Vietnam"},{"name":"Hung Vuong Hospital Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam Nhat","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Endocrinology Clinic Hanh Phuc International Hospital Thu\u1eadn An Binh Duong Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngoc Thanh","family":"Truong","sequence":"additional","affiliation":[{"name":"Hung Vuong Hospital Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuyet Thi\u2010Diem","family":"Hoang","sequence":"additional","affiliation":[{"name":"Hung Vuong Hospital Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trang Nguyen\u2010Khanh","family":"Huynh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Pham Ngoc Thach University of Medicine Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ha Le\u2010Bao","family":"Tran","sequence":"additional","affiliation":[{"name":"Faculty of Biology and Biotechnology University of Science Ho Chi Minh City Vietnam"},{"name":"Laboratory of Tissue Engineering and Biomedical Materials University of Science Ho Chi Minh City Vietnam"},{"name":"Vietnam National University Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.06.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoab021"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1335139"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2022.01.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoaa034"},{"key":"e_1_2_9_7_1","article-title":"Cleavage\u2010Stage Versus Blastocyst\u2010Stage Embryo Transfer in Assisted Reproductive Technology","volume":"5","author":"Glujovsky D.","year":"2022","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_9_8_1","volume-title":"The Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta\u2010Analyses","author":"Wells G.","year":"2011"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2021.1953465"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-019-05236-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-021-02321-y"},{"key":"e_1_2_9_12_1","first-page":"264","article-title":"Pregnancy Outcomes of Frozen\u2010Thawed Blastocysts Versus Blastocysts Derived From Frozen\u2010Thawed Cleavage Embryos: A Retrospective Study","volume":"19","author":"Tran H. 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