{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:39:56Z","timestamp":1783568396855,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":259,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine & Biology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Purpose<\/jats:title>\n \n Preimplantation genetic testing for monogenic disorders (\n PGT<\/jats:styled-content>\n \u2010M) offers\n \n BRCA<\/jats:italic>\n <\/jats:styled-content>\n variant carriers the option of preventing hereditary cancer transmission. We investigated the awareness and attitudes toward\n PGT<\/jats:styled-content>\n \u2010M among patients with breast cancer who underwent fertility preservation.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A questionnaire\u2010based survey was administered to 264 patients with breast cancer who were eligible for oocyte or embryo cryopreservation at in\u00a0vitro fertilization clinics between October 2024 and March 2025. A total of 161 valid responses were analyzed. The survey assessed\n \n BRCA<\/jats:italic>\n <\/jats:styled-content>\n testing status,\n PGT<\/jats:styled-content>\n \u2010M awareness, willingness to undergo\n PGT<\/jats:styled-content>\n \u2010M, and opinions on future availability.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The uptake rate of\n \n BRCA1<\/jats:styled-content>\n \/2\n <\/jats:italic>\n testing was 53.4%; 14% of the respondents were variant carriers. Only 16.8% had prior awareness of\n PGT<\/jats:styled-content>\n \u2010M, and 47.8% expressed a willingness to use\n PGT<\/jats:styled-content>\n \u2010M if available. Among\n \n BRCA<\/jats:italic>\n <\/jats:styled-content>\n \u2010variant carriers, 3.3% reported that they would consider\n PGT<\/jats:styled-content>\n \u2010M, and 75% believed it should be made available upon request. Overall, 68.3% supported information sharing between oncology and fertility providers.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n These findings highlight the importance of expanding reproductive options and patient awareness of\n PGT<\/jats:styled-content>\n \u2010M in the care of patients with hereditary cancer. Discussions should focus on how best to provide accurate information and enable informed reproductive choices for those at genetic risk.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/rmb2.12678","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T10:56:20Z","timestamp":1758106580000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Perspectives on Preimplantation Genetic Testing for Monogenic Disorders Among Japanese Patients With Hereditary Breast Cancer Undergoing Fertility Preservation: Insights From the First Japanese Survey"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8797-1373","authenticated-orcid":false,"given":"Haruhisa","family":"Konishi","sequence":"first","affiliation":[{"name":"IVF Namba Clinic Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiharu","family":"Nakaoka","sequence":"additional","affiliation":[{"name":"IVF Namba Clinic Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anmae","family":"Michiko","sequence":"additional","affiliation":[{"name":"IVF Namba Clinic Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"IVF Namba Clinic Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Kitayama","sequence":"additional","affiliation":[{"name":"IVF Namba Clinic Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kadogami","sequence":"additional","affiliation":[{"name":"IVF Namba Clinic Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoharu","family":"Morimoto","sequence":"additional","affiliation":[{"name":"IVF Namba Clinic Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Katsu","sequence":"additional","affiliation":[{"name":"IVF Namba Clinic Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Fujioka","sequence":"additional","affiliation":[{"name":"IVF Osaka Clinic Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Inoue","sequence":"additional","affiliation":[{"name":"HORAC GRANDFRONT IVF Osaka Clinic, Grand Front Osaka Tower B Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisaku","family":"Fukuda","sequence":"additional","affiliation":[{"name":"IVF Osaka Clinic Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5690-5218","authenticated-orcid":false,"given":"Hiroki","family":"Kurahashi","sequence":"additional","affiliation":[{"name":"IVF Namba Clinic Osaka Japan"},{"name":"Division of Molecular Genetics Center for Medical Science Fujita Health University Toyoake Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2834-2726","authenticated-orcid":false,"given":"Yoshiharu","family":"Morimoto","sequence":"additional","affiliation":[{"name":"HORAC GRANDFRONT IVF Osaka Clinic, Grand Front Osaka Tower B Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoaa021"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010016\u20100035\u2010x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg110"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu132"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoad010"},{"key":"e_1_2_10_7_1","unstructured":"Japanese Society of Obstetrics and Gynecology \u201cGuidelines on the Indications for Preimplantation Genetic Testing for Monogenic Disorders (PGT\u2010M) \u201d (2022) [in 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