{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:33:18Z","timestamp":1782228798723,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:00:00Z","timestamp":1762646400000},"content-version":"vor","delay-in-days":312,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020309","name":"KARL STORZ","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020309","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To identify risk factors that predict the persistence of noncyclical pelvic pain in patients with endometriosis despite receiving hormone therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study examined 164 patients with histopathologically confirmed deep infiltrating endometriosis (DE) and\/or ovarian endometrioma (OV). Clinical data obtained through preoperative face\u2010to\u2010face interviews were analyzed to identify risk factors for persistent pain despite receiving hormonal treatment (defined as visual analog\u2010scale score [VAS] score &gt;\u200930). All patients received preoperative hormonal treatment with progestins, combined oral contraceptives, or gonadotropin\u2010releasing hormone agonists for at least three months prior to surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariable analysis identified several risk factors: OV (odds ratio [OR]: 4.11, 95% confidence interval [CI]: 1.67\u201310.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) versus no OV, noncyclical chronic pelvic pain (VAS score \u2264\u200960: OR: 12.0, 95% CI: 4.17\u201334.6; VAS score &gt;\u200960: OR: 7.03, 95% CI: 2.25\u201321.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) versus no pain, severe dyspareunia (VAS score &gt;\u200960) (OR: 6.73, 95% CI: 4.17\u201334.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) versus no dyspareunia, and a previous cesarean section (OR: 9.53, 95% CI: 1.54\u201359.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) versus no previous cesarean section.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with ovarian endometrioma, noncyclical chronic pelvic pain, severe dyspareunia, and a history of cesarean section are at an increased risk for persistent pain despite hormonal treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.12684","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T06:16:43Z","timestamp":1762755403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of Risk Factors Associated With Persistent Noncyclic Pelvic Pain Despite Hormonal Treatment in Patients With Endometriosis"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9297-6515","authenticated-orcid":false,"given":"Sachiko","family":"Matsuzaki","sequence":"first","affiliation":[{"name":"CHU Clermont\u2010Ferrand Chirurgie Gyn\u00e9cologique  Clermont\u2010Ferrand France"},{"name":"Universit\u00e9 Clermont Auvergne Institut Pascal, UMR6602, CNRS\/UCA\/SIGMA  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Luc","family":"Pouly","sequence":"additional","affiliation":[{"name":"CHU Clermont\u2010Ferrand Chirurgie Gyn\u00e9cologique  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Canis","sequence":"additional","affiliation":[{"name":"CHU Clermont\u2010Ferrand Chirurgie Gyn\u00e9cologique  Clermont\u2010Ferrand France"},{"name":"Universit\u00e9 Clermont Auvergne Institut Pascal, UMR6602, CNRS\/UCA\/SIGMA  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17403-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-021-01545-5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.05.004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu046"},{"key":"e_1_2_11_6_1","article-title":"Gonadotrophin\u2010Releasing Hormone Analogues for Pain Associated With Endometriosis","volume":"2010","author":"Brown J.","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.5653\/cerm.2023.06128"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph18040588"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)81391-X"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der462"},{"key":"e_1_2_11_11_1","first-page":"583","article-title":"The Pattern of Estradiol and Progesterone Differs in Serum and Tissue of Benign and Malignant Ovarian Tumors","volume":"21","author":"Lindgren P. R.","year":"2002","journal-title":"International Journal of Oncology"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1154"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.09.028"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-021-00364-5"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-021-09666-w"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des313"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjpt.2023.100537"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(23)00324-7"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008797.pub2"},{"key":"e_1_2_11_20_1","article-title":"Surgical Interventions for the Management of Chronic Pelvic Pain in Women","volume":"12","author":"Leonardi M.","year":"2021","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2024.08.006"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2023.06.020"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60101677"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjae.2021.11.008"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0238634"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2025.105388"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001939"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11020467"},{"key":"e_1_2_11_29_1","first-page":"143","article-title":"Endometriosis\u2010Associated Chronic Pelvic Pain","volume":"4","author":"Karp B. I.","year":"2023","journal-title":"Medicus"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00393-7"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12684","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rmb2.12684","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T08:56:43Z","timestamp":1769590603000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmb2.12684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/rmb2.12684"],"URL":"https:\/\/doi.org\/10.1002\/rmb2.12684","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12684"}}