{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:27:26Z","timestamp":1789997246778,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To study whether subchorionic hematoma (SCH) location and size in early pregnancy affect placenta accreta spectrum (PAS) risk in hormone replacement cycles (HRC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study of 685 singleton live births following frozen\u2013thawed embryo transfer in HRC (November 2018\u2013September 2023) at a single fertility clinic. SCH location (cervical\u2010side, mid\u2010cavity, or fundal\u2010side) and size (&lt;\u200910% or &gt;\u200950% of gestational sac), assessed by first\u2010trimester ultrasound, were evaluated for association with PAS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The presence of SCH showed a trend toward increased PAS frequency (adjusted Risk Ratio (RR) 1.56, 95% Confidence Interval (CI) 0.87\u20132.80). Location\u2010specific analysis revealed that cervical\u2010side SCH conferred significantly elevated PAS risk compared to those without cervical\u2010side SCH (adjusted RR 2.21, 95% CI 1.18\u20134.15), whereas mid\u2010cavity SCH (adjusted RR 1.74, 95% CI 0.94\u20133.22) and fundal\u2010side SCH (adjusted RR 0.59, 95% CI 0.20\u20131.76) showed no significant association. Regarding SCH size, larger hematomas (&gt;\u200950% of gestational sac) were not associated with increased PAS risk compared to smaller hematomas (&lt;\u200910%) (adjusted RR 0.59, 95% CI 0.16\u20132.13).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cervical\u2010side SCH, but not mid\u2010cavity or fundal\u2010side hematomas, was associated with increased PAS risk in HRC pregnancies. These findings suggest that SCH location may serve as a key prognostic marker in HRC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.70005","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T07:26:42Z","timestamp":1766561202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk of Placenta Accreta Spectrum With Early Pregnancy Subchorionic Hematoma Location and Size in Hormone Replacement Cycles"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1730-6693","authenticated-orcid":false,"given":"Shuhei","family":"So","sequence":"first","affiliation":[{"name":"Department of Reproductive and Perinatal Medicine Hamamatsu University School of Medicine  Shizuoka Japan"},{"name":"Tawara IVF Clinic  Shizuoka 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