{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:11:50Z","timestamp":1784823110190,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019091","name":"Key Research and Development Program of Hunan Province of China","doi-asserted-by":"publisher","award":["2023SK2069"],"award-info":[{"award-number":["2023SK2069"]}],"id":[{"id":"10.13039\/501100019091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To study incidence, clinical risk factors, and pregnancy outcomes of trophectoderm\u2010 and inner cell mass\u2013poor\u2010quality blastocysts in single blastocyst transfer cycles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A retrospective cohort study included patients who underwent their first single blastocyst transfer cycle. A multivariate log\u2010binomial regression model with COPY methods was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of having no transferable high\u2010quality blastocysts was 33.8% (15\u2009685\/46\u2009433). Maternal age, BMI, infertility duration, cycle number, embryo developmental stage, and transfer strategies are independent risk factors that affect the quality of blastocysts (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). After adjusting for 11 confounding factors, the CPR and LBR significantly decreased across the groups in the order of high\u2010grade blastocysts, low TE grade, and low ICM grade. Late\u2010term miscarriage, preterm birth, singleton live birth, low birth weight of singleton, and birth weight of singleton were not statistically different between three groups. Low TE grade blastocysts exhibited significantly higher rates of small gestational sacs compared to high\u2010grade blastocysts, while low ICM grade blastocysts were associated with a significantly higher incidence of small yolk sacs compared to both high\u2010grade blastocysts and those with low TE grade.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Differential impacts of blastocyst component quality on early embryonic development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.70006","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:49:53Z","timestamp":1767167393000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidence, Clinical Risk Factors, and Pregnancy Outcomes of Trophectoderm\u2010 and Inner Cell Mass\u2013Poor\u2010Quality Blastocysts in Single Blastocyst Transfer Cycles: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"25","author":[{"given":"Longbin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Reproductive and Stem Cell Engineering, School of Basic Medical Central South University  Changsha Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6264-6120","authenticated-orcid":false,"given":"Yangqin","family":"Peng","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive and Genetic Hospital of CITIC\u2010Xiangya  Changsha Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuoping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive and Genetic Hospital of CITIC\u2010Xiangya  Changsha Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Gu","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive and Genetic Hospital of CITIC\u2010Xiangya  Changsha Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Reproductive and Stem Cell Engineering, School of Basic Medical Central South University  Changsha Hunan People's Republic of China"},{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive and Genetic Hospital of CITIC\u2010Xiangya  Changsha Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Reproductive and Stem Cell Engineering, School of Basic Medical Central South University  Changsha Hunan People's Republic of China"},{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive and Genetic Hospital of CITIC\u2010Xiangya  Changsha Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhi","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Reproductive and Stem Cell Engineering, School of Basic Medical Central South University  Changsha Hunan People's Republic of China"},{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive and Genetic Hospital of CITIC\u2010Xiangya  Changsha Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/HUMREP\/DEAA186"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/HUMREP\/DEZ078"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead045"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.rbmo.2021.01.019","article-title":"Should We Look for a Low\u2010Grade Threshold for Blastocyst Transfer? 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