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These results were used to establish prediction models for estimating collagen content using support vector regression (\n                      <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>\n                      ) and ridge regression (Ridge). For patients who received gonadotropin\u2010releasing hormone analogs (41 uterine leiomyomas),\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      was performed before and after treatment. Correlation between the collagen content estimated by prediction models and tumor reduction rate by\n                      <jats:styled-content style=\"fixed-case\">GnRHa<\/jats:styled-content>\n                      treatment was investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>\n                      and ridge models were able to estimate the collagen content with high accuracy [\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>R<\/jats:italic>\n                        <jats:sup>2<\/jats:sup>\n                      <\/jats:styled-content>\n                      : 0.579 (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 0.33\u20130.66) and 0.570 (0.27\u20130.62) in cross validation and 0.648 (0.31\u20130.85) and 0.675 (0.34\u20130.86) in Internal Validation]. Significant negative correlations [\n                      <jats:italic>R<\/jats:italic>\n                      : \u22120.714 (\u22120.58 to \u22120.81) and \u22120.700 (\u22120.56 to \u22120.80)] were shown between the estimated collagen content and the tumor reduction rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Collagen content of uterine leiomyomas can be estimated by machine learning models using\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      data and can predict the effect of drug therapy on tumor reduction.\n                    <\/jats:p>\n                  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