{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T22:57:21Z","timestamp":1769727441381,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>A non\u2010consanguineous couple with recurrent pregnancy loss was found to be carriers of two different balanced reciprocal translocations: 46,XX,t(13;16)(q14;q23) and 46,XY,t(4;12)(q21.1;q15). They underwent IVF with PGT\u2010SR, from which seven blastocysts were obtained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome<\/jats:title>\n                    <jats:p>Only one embryo was identified as both euploid and structurally balanced. This embryo was transferred in a hormone replacement cycle, resulting in a successful pregnancy and the birth of a healthy male infant who inherited both parental balanced translocations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case demonstrates the feasibility and utility of PGT\u2010SR in rare dual\u2010carrier cases, underscoring the importance of tailored genetic counseling, careful embryo selection, and realistic prognostic discussion for couples with complex chromosomal abnormalities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.70022","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T11:54:28Z","timestamp":1769687668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful Live Birth Following\n                    <scp>PGT<\/scp>\n                    \u2010\n                    <scp>SR<\/scp>\n                    in a Couple Who Were Both Carriers of Balanced Reciprocal Translocations Identified During Recurrent Pregnancy Loss Workup: A Case Report"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5647-2184","authenticated-orcid":false,"given":"Hiroaki","family":"Negishi","sequence":"first","affiliation":[{"name":"Reproductive Medicine Yokota Maternity Hospital  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Higeta","sequence":"additional","affiliation":[{"name":"Perinatal Medical Center Gunma University Hospital  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoh","family":"Maki","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Yokota Maternity Hospital  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuko","family":"Satoh","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Yokota Maternity Hospital  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youko","family":"Matsumiya","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Yokota Maternity Hospital  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanami","family":"Takano","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Yokota Maternity Hospital  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemi","family":"Yokota","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Yokota Maternity Hospital  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikako","family":"Yokota","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Yokota Maternity Hospital  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Yokota","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Yokota Maternity Hospital  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.10.035"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3306"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey036"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der068"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199812)18:13<1437::AID-PD497>3.0.CO;2-P"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.10.013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.22074\/IJFS.2021.137626.1027"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1136\/bmj.38735.459144.2F","article-title":"Reproductive Outcome After Chromosome Analysis in Couples With Two or More Miscarriages: Case\u2010Control Study","volume":"332","author":"Franssen M. 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