{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:45:36Z","timestamp":1792611936576,"version":"4.5.0"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":46,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022MH009"],"award-info":[{"award-number":["ZR2022MH009"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101712"],"award-info":[{"award-number":["82101712"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To identify the specific risk factors associated with unexplained infertility (UI) among infertile couples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study analyzing UI risk factors, focusing on 5465 infertile couples who completed their first full in\u00a0vitro fertilization\/intracytoplasmic sperm injection (IVF\/ICSI) cycle out of a total cohort of 62201 infertile couples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 5465 UI couples, 3400 achieved a live birth (cumulative live birth rate\u2009=\u200962.2%). Multivariate logistic regression indicated the key negative predictors included: female age \u2265\u200935\u2009years (odds ratio [OR]: 0.63; 95% confidence interval [CI]: 0.51\u20130.78;\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.001), male age (OR: 0.98; 95% CI: 0.96\u20130.99;\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.015), Female body mass index \u2265\u200927.5\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (OR: 0.78; 95% CI: 0.62\u20130.97;\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.028), low anti\u2010M\u00fcllerian hormone (AMH) (AMH &lt;\u20091.2\u2009ng\/mL) (OR: 0.64; 95% CI: 0.52\u20130.77;\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.001), and a mid\u2010range endometrial thickness (EMT) (EMT 0.7\u20131.0\u2009cm) (OR: 0.77; 95% CI: 0.66\u20130.89;\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.001). A higher number of retrieved oocytes positively correlated with cumulative live birth (CLB) (OR: 1.02; 95% CI: 1.01\u20131.04;\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.039).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence of UI was 8.8% in our population, with 62.2% achieving CLB after one complete IVF\/ICSI cycle. Female age and ovarian reserve indicators emerged as the main factors influencing oocyte yield, embryo acquisition, and CLB outcomes in UI patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.70025","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T10:32:55Z","timestamp":1771237975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of Risk Factors Affecting Cumulative Live Birth in Couples With Unexplained Infertility Undergoing IVF\/ICSI"],"prefix":"10.1002","volume":"25","author":[{"given":"Ran","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health Shandong University  Jinan Shandong People's Republic of China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong University  Jinan Shandong People's Republic of China"},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education  Jinan Shandong People's Republic of China"},{"name":"Shandong Technology Innovation Center for Reproductive Health  Jinan Shandong People's Republic of China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health  Jinan Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health Shandong University  Jinan Shandong People's Republic of China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong University  Jinan Shandong People's Republic of China"},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education  Jinan Shandong People's Republic of China"},{"name":"Shandong Technology Innovation Center for Reproductive Health  Jinan Shandong People's Republic of China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health  Jinan Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyu","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health Shandong University  Jinan Shandong People's Republic of China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong University  Jinan Shandong People's Republic of China"},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education  Jinan Shandong People's Republic of China"},{"name":"Shandong Technology Innovation Center for Reproductive Health  Jinan Shandong People's Republic of China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health  Jinan Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Song","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health Shandong University  Jinan Shandong People's Republic of China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong University  Jinan Shandong People's Republic of China"},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education  Jinan Shandong People's Republic of China"},{"name":"Shandong Technology Innovation Center for Reproductive Health  Jinan Shandong People's Republic of China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health  Jinan Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengxiang","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health Shandong University  Jinan Shandong People's Republic of China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong University  Jinan Shandong People's Republic of China"},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education  Jinan Shandong People's Republic of China"},{"name":"Shandong Technology Innovation Center for Reproductive Health  Jinan Shandong People's Republic of China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health  Jinan Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6433-2192","authenticated-orcid":false,"given":"Yujie","family":"Dang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health Shandong University  Jinan Shandong People's Republic of China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong University  Jinan Shandong People's Republic of China"},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education  Jinan Shandong People's Republic of China"},{"name":"Shandong Technology Innovation Center for Reproductive Health  Jinan Shandong People's Republic of China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health  Jinan Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health Shandong University  Jinan Shandong People's Republic of China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong University  Jinan Shandong People's Republic of China"},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education  Jinan Shandong People's Republic of China"},{"name":"Shandong Technology Innovation Center for Reproductive Health  Jinan Shandong People's Republic of China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health  Jinan Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i5735"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.09.015"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000000043"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)33038\u20106"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.05.063"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.10.014"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.04.022"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2010.02.014"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.900829"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001586"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(96)05291\u20109"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev268"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez223"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.11.014"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev263"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)32843\u20105"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(03)15268\u20103"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.02.005"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp036"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.03.001"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.22074\/ijfs.2023.1988282.1428"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015\u20102474"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2024.02.044"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.01.025"},{"issue":"2","key":"e_1_2_10_26_1","first-page":"1","article-title":"Births: Final Data for 2019","volume":"70","author":"Martin J. A.","year":"2021","journal-title":"National Vital Statistics Reports"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007222.pub4"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.558819"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoac022"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10956"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2024.07.017"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.08.1435"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154\u2010022\u201009712\u20101"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1801040"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1354-1"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032\u2010021\u201000631\u20101"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25136855"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.11.162"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13554"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1024151210536"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv004"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14103385"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-99596-6_1"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512790"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002187"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.04.039"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez301"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00535\u20103"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmad026"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2021.101656"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032995"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.02.009"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19411"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.04.063"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958\u2010018\u20100414\u20102"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2013.08.011"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey281"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e34043"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0015\u20100282(03)00339\u2010x"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e15723"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz7602"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.70025","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rmb2.70025","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.70025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:22:44Z","timestamp":1792610564000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmb2.70025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/rmb2.70025"],"URL":"https:\/\/doi.org\/10.1002\/rmb2.70025","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70025"}}