{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:49:54Z","timestamp":1791798594217,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":123,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFB3604703"],"award-info":[{"award-number":["2022YFB3604703"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp;amp; Biology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study investigated ovarian response, safety, and reproductive outcomes in patients with hematological diseases undergoing controlled ovarian stimulation (COS) for emergency fertility preservation (FP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed female patients with hematological diseases receiving COS for emergency FP at our center from January 2016 to February 2025. Outcomes were compared by menstrual cycle phase at stimulation initiation, protocols, and chemotherapy exposure, with follow\u2010up data on hematologic disease status, utilization of cryopreserved oocytes\/embryos, ovarian function, marital, and reproductive collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No statistically significant differences in ovarian response were detected according to the phase of the menstrual cycle at stimulation initiation or between the gonadotropin\u2010releasing hormone antagonist (GnRH\u2010ant) and progestin\u2010primed ovarian stimulation (PPOS) protocols. Chemotherapy exposure within 3\u2009months was associated with lower oocyte and mature oocyte yield. Most patients underwent hematopoietic stem cell transplantation (HSCT), and 92.31% developed premature ovarian insufficiency (POI). Six patients underwent warming of oocytes\/embryos, achieving two live births including one twin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>During emergency FP in patients with hematological diseases, random\u2010start COS using either GnRH\u2010ant or PPOS protocols yields comparable outcomes, supporting its feasibility and flexible application in time\u2010constrained settings. Recent chemotherapy exposure may adversely affect COS outcomes and should be considered when planning treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.70057","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:43:00Z","timestamp":1777894980000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emergency Fertility Preservation in Hematological Diseases: Ovarian Response and Real\u2010World Outcomes From China"],"prefix":"10.1002","volume":"25","author":[{"given":"Jinghua","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University People's Hospital  Beijing China"},{"name":"Reproductive Medical Center Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University People's Hospital  Beijing China"},{"name":"Reproductive Medical Center Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University People's Hospital  Beijing China"},{"name":"Reproductive Medical Center Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianliu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University People's Hospital  Beijing China"},{"name":"Reproductive Medical Center Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanping","family":"Xu","sequence":"additional","affiliation":[{"name":"Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8984-9888","authenticated-orcid":false,"given":"Li","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University People's Hospital  Beijing China"},{"name":"Reproductive Medical Center Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2013.07.014"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002235"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.79"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-019-0605-2"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-021-01431-6"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2025.217569"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-020-01778-7"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2024.02.002"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05482-4"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2023.101115"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2021.09.010"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.09.013"},{"issue":"4","key":"e_1_2_12_14_1","first-page":"352","article-title":"Ovarian Response After Random\u2010Start Controlled Ovarian Stimulation to Cryopreserve Oocytes in Cancer Patients","volume":"22","author":"Campos A. 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