{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T23:26:51Z","timestamp":1793575611834,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":186,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571880"],"award-info":[{"award-number":["82571880"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This meta\u2010analysis evaluates the efficacy and safety of intrauterine autologous platelet\u2010rich plasma (PRP) infusion in patients with recurrent implantation failure (RIF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Following PRISMA guidelines, we systematically searched major databases and included 10 randomized controlled trials (RCTs,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091\u2009188). Study quality was assessed using the Cochrane RoB 2.0 tool.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PRP infusion significantly improved clinical pregnancy rate (RR\u2009=\u20092.23, 95% CI 1.84\u20132.69) and live birth rate (RR\u2009=\u20093.74, 95% CI 2.68\u20135.22) without increasing miscarriage risk. Subgroup analysis indicated that a 0.5\u2009mL PRP volume was as effective as 0.5\u20131.0\u2009mL, and a notably greater treatment effect was observed in blastocyst transfer cycles compared to cleavage\u2010stage embryo transfers, suggesting potential enhanced benefit in this subgroup.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intrauterine PRP infusion is an effective and safe treatment for RIF. The findings on dose equivalence and differential efficacy by embryo stage offer valuable insights for optimizing clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.70070","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T08:18:29Z","timestamp":1783325909000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of Intrauterine Infusion of Autologous Platelet\u2010Rich Plasma on Assisted Reproductive Outcomes in Patients With Recurrent Implantation Failure: A Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6689-8964","authenticated-orcid":false,"given":"Xinhong","family":"Liang","sequence":"first","affiliation":[{"name":"Reproductive Medical Center The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi China"},{"name":"Reproductive 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