{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:42:16Z","timestamp":1792608136547,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":253,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Since 2023, our university hospital has incorporated hyaluronan\u2010enriched transfer medium (HETM) into all frozen\u2013thawed embryo transfers (FETs). This study aimed to evaluate whether HETM improved clinical pregnancy rates in FET, particularly in patients with recurrent implantation failure (RIF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 368 FET cycles using a conventional hyaluronan\u2010free transfer medium and 358 FET cycles using HETM, in which thawed embryos were incubated for 2\u20134\u2009h before transfer. The main outcome was clinical pregnancy. Multiple logistic regression was used to evaluate the effectiveness of HETM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of patients was 37.4\u2009years (standard deviation\u2009=\u20094.2), and RIF, defined as failure to achieve pregnancy after two or more previous embryo transfers, accounted for 51.2%. Clinical pregnancy rates were significantly higher in the HETM group (37.7%) than in the control group (27.2%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Stratified analyses showed that HETM was associated with higher clinical pregnancy rates in RIF cycles (adjusted odds ratio\u2009=\u20092.4 [95% confidence interval: 1.4\u20133.9]). An additional analysis restricted to patients with three or more previous failed embryo transfers showed similar results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates HETM use is associated with improved clinical pregnancy rates in FET, particularly in cases of RIF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.70074","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:05:08Z","timestamp":1789160708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Hyaluronan\u2010Enriched Transfer Medium in Frozen\u2013Thawed Embryo Transfer: A Retrospective Single\u2010Center University Hospital Study Using a Historical Cohort"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0743-9719","authenticated-orcid":false,"given":"Shoko","family":"Toyoda","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Chik","family":"Jwa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Kamishiro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Kagawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuho","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(84)90750-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129039-200609000-00012"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(87)90120-5"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-012-9758-2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.07.1294"},{"issue":"9","key":"e_1_2_11_7_1","article-title":"Hyaluronic Acid in Embryo Transfer Media for Assisted Reproductive Technologies","volume":"9","author":"Heymann D.","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1170727"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-023-07083-9"},{"issue":"1","key":"e_1_2_11_10_1","article-title":"Effect of Hyaluronic Acid\u2010Containing Transfer Media (EmbryoGlue(R)) on the Live Birth Rate in Frozen Thawed Embryo Transfer Cycles","volume":"16","author":"Bhoi N. R.","year":"2024","journal-title":"Cureus"},{"issue":"5","key":"e_1_2_11_11_1","article-title":"Efficacy of Hyaluronan\u2010Enriched Transfer Medium for Low\u2010Grade Frozen Embryo Transfer","volume":"15","author":"Horiuchi Y.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.02.015"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12051"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead184"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-018-4937-8"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.10.019"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.70074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rmb2.70074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.70074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:10:57Z","timestamp":1792606257000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmb2.70074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/rmb2.70074"],"URL":"https:\/\/doi.org\/10.1002\/rmb2.70074","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70074"}}