{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T23:26:43Z","timestamp":1793575603540,"version":"4.5.0"},"reference-count":70,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":229,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007234","name":"University of Chicago","doi-asserted-by":"publisher","award":["Start\u2010up Fund"],"award-info":[{"award-number":["Start\u2010up Fund"]}],"id":[{"id":"10.13039\/100007234","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002562","name":"Sunchon National University","doi-asserted-by":"publisher","award":["Glocal University Fund"],"award-info":[{"award-number":["Glocal University Fund"]}],"id":[{"id":"10.13039\/501100002562","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102026\u201025476186"],"award-info":[{"award-number":["RS\u20102026\u201025476186"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in reproductive\u2010age women. Several published studies demonstrated the therapeutic potential of vitamin D on PCOS condition, but vitamin D supplementation leads to only modest improvements. Doxercalciferol (Dox) is a highly potent vitamin D receptor (VDR) agonist that binds to VDR with at least 150 times greater affinity than other vitamin D compounds. In this study, we hypothesized that the therapeutic potential of Dox may reverse PCOS\u2010related phenotypes more efficiently.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We first analyzed the regulatory potential of Dox in fat metabolism by comparing adipocyte proliferation and differentiation in our in\u00a0vitro model. We also injected Dox into our mouse model of PCOS to analyze the therapeutic effect of Dox treatment on various PCOS\u2010related parameters and fertility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>Dox treatment inhibited the proliferation of both adipose lineage cells and androgen\u2010producing H295R cells in a dose\u2010dependent manner. PCOS\u2010related outcomes such as body weight and fertility rate were significantly reversed in Dox\u2010treated PCOS mice model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study revealed that vitamin D analogs are a promising family of compounds for reducing body weight and reversing infertility in an animal model of PCOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.70082","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:58:39Z","timestamp":1787047119000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Vitamin D Analogs Doxercalciferol Induces Weight Loss and Improves Fertility in a Mouse Model of Polycystic Ovary Syndrome"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9130-8478","authenticated-orcid":false,"given":"Hang\u2010soo","family":"Park","sequence":"first","affiliation":[{"name":"Department of Biomedical Science Sunchon National University  Suncheon Republic of Korea"},{"name":"Research Institute of Basic Sciences Sunchon National University  Suncheon Republic of Korea"},{"name":"Department of Obstetrics and Gynecology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0520-4673","authenticated-orcid":false,"given":"Ana","family":"Corachan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Chicago  Chicago Illinois USA"},{"name":"IVI Foundation, Instituto de Investigaci\u00f3n Sanitaria La Fe  Valencia Valencia 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