{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T08:34:47Z","timestamp":1793003687553,"version":"4.5.0"},"reference-count":76,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":267,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Reproductive aging is increasingly recognized as a major contributor to infertility in both women and men. Although traditionally linked to endocrine decline, emerging evidence suggests that mitochondrial dysfunction is a central mechanism underlying impaired gamete quality and reduced reproductive capacity. This review aimed to evaluate the role of mitochondrial deterioration in reproductive aging and to examine the therapeutic potential of mitochondrial\u2010targeted phytochemicals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A narrative review of experimental, translational, and clinical studies was conducted focusing on mitochondrial dynamics, oxidative stress, bioenergetic impairment, and phytochemical\u2010based interventions in reproductive aging. Relevant evidence involving oocytes, spermatozoa, and the reproductive microenvironment was critically synthesized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Aging\u2010associated mitochondrial dysfunction was consistently associated with impaired\n                      <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>\n                      production, excessive reactive oxygen species generation, mitochondrial\n                      <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                      damage, and disrupted cellular homeostasis, leading to reduced oocyte competence, sperm motility, and embryonic development. Several phytochemicals, including resveratrol, quercetin, epigallocatechin gallate, astaxanthin, lycopene, berberine, and coenzyme\n                      <jats:styled-content style=\"fixed-case\">Q10<\/jats:styled-content>\n                      , demonstrated protective effects through modulation of\n                      <jats:styled-content style=\"fixed-case\">SIRT1<\/jats:styled-content>\n                      \u2013\n                      <jats:styled-content style=\"fixed-case\">PGC<\/jats:styled-content>\n                      \u20101\u03b1,\n                      <jats:styled-content style=\"fixed-case\">AMPK<\/jats:styled-content>\n                      , Nrf2, and\n                      <jats:styled-content style=\"fixed-case\">PINK1<\/jats:styled-content>\n                      \u2013Parkin signaling pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Targeting mitochondrial bioenergetics with phytochemicals may provide a promising strategy for preserving fertility and extending reproductive lifespan, although further large\u2010scale clinical validation is required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.70086","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:55:14Z","timestamp":1790398514000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial\u2010Targeted Phytochemicals in Reproductive Aging: Mechanisms and Translational Potential"],"prefix":"10.1002","volume":"25","author":[{"given":"Binarwan","family":"Halim","sequence":"first","affiliation":[{"name":"Faculty of Medicine Universitas Prima Indonesia  Medan Indonesia"},{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine Universitas Sumatera Utara  Medan 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