{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:46:59Z","timestamp":1791794819419,"version":"4.3.4"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":230,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009945","name":"Merck KGaA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009945","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp;amp; Biology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This paper critically evaluates Sekiguchi et\u00a0al.'s study of vaginal progesterone dose, serum progesterone thresholds, and reproductive outcomes in hormone replacement therapy frozen embryo transfer (HRT\u2010FET) cycles. The study conflates descriptive, predictive, and causal aims without a clearly prespecified primary question, limiting interpretability. Major concerns include non\u2010random treatment allocation, potential residual confounding, absence of a causal framework for covariate selection, unaddressed temporal confounding related to Japan's 2022 insurance reform, and exclusion of an available progesterone formulation. Additionally, formulation specific pharmacokinetics, single\u2010time\u2010point progesterone measurement, and internally derived thresholding limit comparability, predictive validity, and clinical applicability.<\/jats:p>","DOI":"10.1002\/rmb2.70088","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T05:30:43Z","timestamp":1787203843000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Appraisal of \u201cMicronized Vaginal Progesterone Dose and Serum Progesterone Thresholds Determine Reproductive Outcomes in Frozen\u2013Thawed Embryo Transfer With Hormone Replacement Therapy\u201d"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4429-396X","authenticated-orcid":false,"given":"I\u2010Hsuan","family":"Wu","sequence":"first","affiliation":[{"name":"Merck Healthcare KGaA  Darmstadt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan\u2010Enrique","family":"Schwarze","sequence":"additional","affiliation":[{"name":"Merck Healthcare KGaA  Darmstadt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4916-9918","authenticated-orcid":false,"given":"Christoph","family":"Helwig","sequence":"additional","affiliation":[{"name":"Merck Healthcare KGaA  Darmstadt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"D'Hooghe","sequence":"additional","affiliation":[{"name":"Global Medical Affairs Fertility, Research and Development, Merck Healthcare KGaA  Darmstadt Germany"},{"name":"Department of Development and Regeneration, Laboratory of Endometrium, Endometriosis &amp; Reproductive Medicine KU Leuven  Leuven Belgium"},{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences Yale University Medical School  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilka","family":"Schellschmidt","sequence":"additional","affiliation":[{"name":"Merck Healthcare KGaA  Darmstadt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.70039"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)00139\u20109"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2025.05.168"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.16234"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12300"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.70088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rmb2.70088","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.70088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:19:06Z","timestamp":1791793146000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmb2.70088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/rmb2.70088"],"URL":"https:\/\/doi.org\/10.1002\/rmb2.70088","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70088"}}