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Clinical trials have shown that melatonin is efficient in preventing cell damage under acute (sepsis, asphyxia in newborns) and chronic states (metabolic and neurodegenerative diseases, cancer, inflammation, aging). The beneficial effects of melatonin can be explained by its properties as a potent antioxidant and antioxidant enzyme inducer, a regulator of apoptosis and a stimulator of immune functions. These effects support the use of melatonin in viral infections, which are often associated with inflammatory injury and increases in oxidative stress. In fact, melatonin has been used recently to treat several viral infections, which are summarized in this review. The role of melatonin in infections is also discussed herein. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/rmv.1714","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T07:32:04Z","timestamp":1334734324000},"page":"323-338","source":"Crossref","is-referenced-by-count":77,"title":["Beneficial actions of melatonin in the management of viral infections: a new use for this \u201cmolecular handyman\u201d?"],"prefix":"10.1002","volume":"22","author":[{"given":"Jose Antonio","family":"Boga","sequence":"first","affiliation":[{"name":"Department of Cellular and Structural Biology UT Health Science Center  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Coto\u2010Montes","sequence":"additional","affiliation":[{"name":"Department of Cellular and Structural Biology UT Health Science Center  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio A.","family":"Rosales\u2010Corral","sequence":"additional","affiliation":[{"name":"Department of Cellular and Structural Biology UT Health Science Center  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dun\u2010Xian","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cellular and Structural Biology UT Health Science Center  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russel J.","family":"Reiter","sequence":"additional","affiliation":[{"name":"Department of Cellular and Structural Biology UT Health Science Center  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01543a060"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01531a060"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3881822"},{"key":"e_1_2_11_5_1","first-page":"375","article-title":"Synchronization of mammalian circadian rhythms by melatonin","volume":"21","author":"Armstrong SM","year":"1986","journal-title":"Journal of Neural Transmission. 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