{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:03:01Z","timestamp":1791306181133,"version":"4.3.1"},"reference-count":98,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T00:00:00Z","timestamp":1366588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Science, Sports and Culture of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Japanese Leukemia Foundation and Leuka"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Human T\u2010cell leukemia virus type 1 (HTLV\u20101) was the first retrovirus shown to cause human disease, such as adult T\u2010cell leukemia and HTLV\u20101 associated myelopathy\/tropic spastic paraparesis. HTLV\u20101 mainly infects CD4 T cells and deregulates their differentiation, function and homeostasis, which should contribute to the pathogenesis of HTLV\u20101, for example, inducing transformation of infected CD4 T cells and chronic inflammatory diseases. Therefore, not only virological approach but also immunological approach regarding CD4 T cells are required to understand how HTLV\u20101 causes related human diseases. This review focuses on recent advances in our understanding of the interaction between HTLV\u20101 and the main host cell, CD4 T cells, which should provide us some clue to the mechanisms of HTLV\u20101 mediated pathogenesis. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/rmv.1745","type":"journal-article","created":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T08:13:07Z","timestamp":1366618387000},"page":"269-280","source":"Crossref","is-referenced-by-count":21,"title":["Virological and immunological mechanisms in the pathogenesis of human T\u2010cell leukemia virus type 1"],"prefix":"10.1002","volume":"23","author":[{"given":"Yorifumi","family":"Satou","sequence":"first","affiliation":[{"name":"Laboratory for Virus Control, Institute for Virus Research Kyoto University  Kyoto Japan"},{"name":"Immunology Section, Division of Infectious Diseases Imperial College  London UK"},{"name":"Priority Organization for Innovation and Excellence, Center for AIDS Research Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Laboratory for Virus Control, Institute for Virus Research Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208968"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V50.3.481.481"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/294770a0"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91298-5"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92734-5"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90699-4"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91362-6"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.12.3618"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81466-X"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81148-4"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1080115"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2065"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.475"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2111"},{"key":"e_1_2_11_17_1","first-page":"4862","article-title":"Persistent clonal proliferation of human T\u2010lymphotropic virus type I\u2010infected cells in vivo","volume":"57","author":"Etoh K","year":"1997","journal-title":"Cancer Research"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201906"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/v3050469"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2004.05.005"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.2741\/3420"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.7.3848"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002270"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/348245a0"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/3.8.761"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208970"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001117"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-10-246959"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002231"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000235186.30113.c7"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208978"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208975"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.8.2277"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00242-08"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.21.8112"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.4.11.1875"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-312926"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-11-4350"},{"key":"e_1_2_11_39_1","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.1128\/jvi.64.11.5682-5687.1990","article-title":"In vivo cellular tropism of human T\u2010cell leukemia virus type 1","volume":"64","author":"Richardson JH","year":"1990","journal-title":"Journal of Virology"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.10.3177"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-9-46"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-136770"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1990.tb00563.x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040341"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001274"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830210815"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.24.9733"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-357459"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.05.009"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2189"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-118539"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.02.001"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1992.8.1699"},{"key":"e_1_2_11_54_1","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1128\/JVI.73.6.4575-4581.1999","article-title":"The role of human T\u2010lymphotropic virus type 1 (HTLV\u20101)\u2010infected dendritic cells in the development of HTLV\u20101\u2010associated myelopathy\/tropical spastic paraparesis","volume":"73","author":"Makino M","year":"1999","journal-title":"Journal of Virology"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1745"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-326199"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030152"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28941"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507631103"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-11-4551"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-284141"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.4.1057"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1389"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.2741\/2163"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-154286"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-5-34"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04999.x"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22536"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh366"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00646.x"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24664"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/83707"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/83713"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/83784"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079490"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.12.012"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.03.019"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-6-19"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.2428"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702731"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.3472"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.0669"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-379982"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010722107"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.10.3935"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1991.tb01815.x"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.2.477.477"},{"key":"e_1_2_11_88_1","first-page":"1043","article-title":"Increasing methylation of the CDKN2A gene is associated with the progression of adult T\u2010cell leukemia","volume":"60","author":"Nosaka K","year":"2000","journal-title":"Cancer Research"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-1222"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00073-10"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-11-189845"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-0769"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.12.015"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21328"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1422"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2482"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3801"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20681"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-131185"}],"container-title":["Reviews in Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frmv.1745","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frmv.1745","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.1745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T10:05:32Z","timestamp":1696673132000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmv.1745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,22]]},"references-count":98,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1002\/rmv.1745"],"URL":"https:\/\/doi.org\/10.1002\/rmv.1745","archive":["Portico"],"relation":{},"ISSN":["1052-9276","1099-1654"],"issn-type":[{"value":"1052-9276","type":"print"},{"value":"1099-1654","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,22]]}}}