{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:03:31Z","timestamp":1794006211240,"version":"4.8.0"},"reference-count":60,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute for Science and Technology for Viral Hemorrhagic Fevers","award":["573739\/2008-0"],"award-info":[{"award-number":["573739\/2008-0"]}]},{"name":"National Institute for Science and Technology for Viral Hemorrhagic Fevers","award":["301641\/2010-2"],"award-info":[{"award-number":["301641\/2010-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>\n                    Yellow fever is a viral hemorrhagic fever, which affects people living in Africa and South America and is caused by the yellow fever virus, the prototype species in the\n                    <jats:italic>Flavivirus<\/jats:italic>\n                    genus (\n                    <jats:italic>Flaviviridae<\/jats:italic>\n                    family). Yellow fever virus infection can produce a wide spectrum of symptoms, ranging from asymptomatic infection or oligosymptomatic illness to severe disease with a high fatality rate. In this review, we focus in the mechanisms associated with the physiopathology of yellow fever in humans and animal models. It has been demonstrated that several factors play a role in the pathological outcome of the severe form of the disease including direct viral cytopathic effect, necrosis and apoptosis of hepatocyte cells in the midzone, and a minimal inflammatory response as well as low\u2010flow hypoxia and cytokine overproduction. New information has filled several gaps in the understanding of yellow fever pathogenesis and helped comprehend the course of illness. Finally, we discuss prospects for an immune therapy in the light of new immunologic, viral, and pathologic tools. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/rmv.1752","type":"journal-article","created":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T02:38:45Z","timestamp":1374460725000},"page":"305-318","source":"Crossref","is-referenced-by-count":90,"title":["Immunity and immune response, pathology and pathologic changes: progress and challenges in the immunopathology of yellow fever"],"prefix":"10.1002","volume":"23","author":[{"given":"Juarez A. S.","family":"Quaresma","sequence":"first","affiliation":[{"name":"N\u00facleo de Medicina Tropical Universidade Federal do Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"},{"name":"Departamento de Patologia Universidade do Estado do Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Pagliari","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele B. A.","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Departamento de Arbovirologia e Febres Hemoprr\u00e1gicas Instituto Evandro Chagas, SVS\/Minist\u00e9rio da Sa\u00fade  Ananindeua Par\u00e1 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I. 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