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A rate\u2010limiting step is provided by nucleo\u2010cytoplasmic capsid export, for which a defined multiregulatory protein complex, namely, the nuclear egress complex (NEC), is assembled comprising both viral and cellular components. The NEC regulates at least 3 aspects of herpesviral nuclear replication: (1) multimeric recruitment of NEC\u2010associated effector proteins, (2) reorganization of the nuclear lamina and membranes, and (3) the docking to nuclear capsids. Here, we review published data and own experimental work that characterizes the NEC of HCMV and other herpesviruses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review of information on nuclear egress of HCMV compared to selected alpha\u2010, beta\u2010, and gamma\u2010herpesviruses: proteomics\u2010based approaches, high\u2010resolution imaging techniques, and functional investigations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A large number of reports on herpesviral NECs have been published during the last two decades, focusing on protein\u2010protein interactions, nuclear localization, regulatory phosphorylation, and functional validation. The emerging picture provides an illustrated example of well\u2010balanced and sophisticated protein networking in virus\u2010host interaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Current evidence refined the view about herpesviral NECs. Datasets published for HCMV, murine CMV, herpes simplex virus, and Epstein\u2010Barr virus illustrate the marked functional consistency in the way herpesviruses achieve nuclear egress. However, this compares with only limited sequence conservation of core NEC proteins and a structural conservation restricted to individual domains. The translational use of this information might help to define a novel antiviral strategy on the basis of NEC\u2010directed small molecules.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmv.1934","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T06:44:03Z","timestamp":1498805043000},"source":"Crossref","is-referenced-by-count":53,"title":["The human cytomegalovirus nuclear egress complex unites multiple functions: Recruitment of effectors, nuclear envelope rearrangement, and docking to nuclear capsids"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3375-850X","authenticated-orcid":false,"given":"Manfred","family":"Marschall","sequence":"first","affiliation":[{"name":"Institute for Clinical and Molecular Virology Friedrich\u2010Alexander University of Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves 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