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The virus belongs to genus <jats:italic>Orthohepevirus<\/jats:italic> in the family <jats:italic>Hepeviridae<\/jats:italic>, which contains 4 major genotypes closely relating to humans. Genotypes 1 and 2 only infect humans whereas genotypes 3 and 4 HEV are harbored in a wide range of animal species worldwide and are zoonotic to humans. Recently, a novel animal strain of HEV has been isolated in farmed rabbits in China, and subsequently more strains were discovered in the rabbit populations in at least 7 other countries. Due to high sequence similarity to genotype 3 HEV, rabbit HEV (rHEV) has been assigned to genotype 3. Experimental study showed that rHEV could infect non\u2010human primate and human, which pose a direct threat to human. Further pathogenesis studies showed laboratory rabbits infected with rHEV and genotype 4 HEV could present similar signs of acute and chronic hepatitis E along with extra\u2010hepatic replication as observed in humans. High mortality and vertical transmission were reproduced in rHEV infected pregnant rabbits. Furthermore, rabbit model was also found suitable for evaluating HEV vaccine efficacy in order to manage zoonotic transmission. These data showed laboratory rabbits could serve as an alternative animal model for HEV study under the current circumstances that HEV propagation is limited in vitro. In general, this review aims at presenting comprehensive up\u2010to\u2010date information about rHEV strains and rabbit model for HEV studies.<\/jats:p>","DOI":"10.1002\/rmv.1961","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T11:22:39Z","timestamp":1510917759000},"source":"Crossref","is-referenced-by-count":51,"title":["An overview: Rabbit hepatitis E virus (HEV) and rabbit providing an animal model for HEV study"],"prefix":"10.1002","volume":"28","author":[{"given":"Lin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences Peking University Health Science Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences Peking University Health Science Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences Peking University Health Science Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61030-6"},{"key":"e_1_2_11_3_1","first-page":"275","article-title":"Hepatitis E in Hetian city. 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