{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:35:20Z","timestamp":1773027320530,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Japan Initiative for Global Research Network on Infectious Diseases (J-GRID)"},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan","doi-asserted-by":"crossref","award":["16H05844, 2016-2019"],"award-info":[{"award-number":["16H05844, 2016-2019"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Middle East respiratory syndrome (MERS) is a respiratory disease caused by MERS coronavirus. Because of lack of vaccination, various studies investigated the therapeutic efficacy of antiviral drugs and supportive remedies. A systematic literature search from 10 databases was conducted and screened for relevant articles. Studies reporting information about the treatment of MERS coronavirus infection were extracted and analyzed. Despite receiving treatment with ribavirin plus IFN, the case fatality rate was as high as 71% in the IFN\u2010treatment group and exactly the same in patients who received supportive treatment only. Having chronic renal disease, diabetes mellitus and hypertension increased the risk of mortality (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), and chronic renal disease is the best parameter to predict the mortality. The mean of survival days from onset of illness to death was 46.6 (95% CI, 30.5\u201062.6) for the IFN group compared with 18.8 (95% CI, 10.3\u201027.4) for the supportive\u2010only group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). Delay in starting treatment, older age group, and preexisting comorbidities are associated with worse outcomes. In conclusion, there is no difference between IFN treatment and supportive treatment for MERS patients in terms of mortality. However, ribavirin and IFN combination might have efficacious effects with timely administration and monitoring of adverse events. Large\u2010scale prospective randomized studies are required to assess the role of antiviral drugs for the treatment of this high mortality infection.<\/jats:p>","DOI":"10.1002\/rmv.1977","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T11:50:41Z","timestamp":1523965841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":128,"title":["Clinical outcomes of current medical approaches for Middle East respiratory syndrome: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"28","author":[{"given":"Mostafa Ebraheem","family":"Morra","sequence":"first","affiliation":[{"name":"Faculty of Medicine Alazhar University  Cairo Egypt"},{"name":"Online Research Club (http:\/\/www.onlineresearchclub.org\/)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Van Thanh","sequence":"additional","affiliation":[{"name":"Online Research Club (http:\/\/www.onlineresearchclub.org\/)"},{"name":"University of Medicine and Pharmacy at Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Gomaa","family":"Kamel","sequence":"additional","affiliation":[{"name":"Online Research Club (http:\/\/www.onlineresearchclub.org\/)"},{"name":"Faculty of Medicine Minia University  Minya Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9145-7115","authenticated-orcid":false,"given":"Ahmed Abdelmotaleb","family":"Ghazy","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shebin El\u2010Kom Teaching Hospital  Shibin El Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M.A.","family":"Altibi","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu Minh","family":"Dat","sequence":"additional","affiliation":[{"name":"Online Research Club (http:\/\/www.onlineresearchclub.org\/)"},{"name":"Pham Ngoc Thach University of Medicine  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Ngoc Xuan","family":"Thy","sequence":"additional","affiliation":[{"name":"Online Research Club (http:\/\/www.onlineresearchclub.org\/)"},{"name":"University of Medicine and Pharmacy at Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Lam","family":"Vuong","sequence":"additional","affiliation":[{"name":"Online Research Club (http:\/\/www.onlineresearchclub.org\/)"},{"name":"University of Medicine and Pharmacy at Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa Reda","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Online Research Club (http:\/\/www.onlineresearchclub.org\/)"},{"name":"Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Ibrahim","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Cairo University  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar Samy","family":"Elabd","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Benha University  Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samreen","family":"Fathima","sequence":"additional","affiliation":[{"name":"Deccan College of Medical Sciences University of Health and Sciences  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran","family":"Le Huy Vu","sequence":"additional","affiliation":[{"name":"University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali S.","family":"Omrani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Infectious Diseases King Faisal Specialist Hospital and Research Centre  Riyadh Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziad A.","family":"Memish","sequence":"additional","affiliation":[{"name":"Ministry of Health  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Leading Graduate School Program, and Graduate School of Biomedical Sciences Nagasaki University  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9543-9440","authenticated-orcid":false,"given":"Nguyen Tien","family":"Huy","sequence":"additional","affiliation":[{"name":"Evidence Based Medicine Research Group &amp; Faculty of Applied Sciences Ton Duc Thang University  Ho Chi Minh City Vietnam"},{"name":"Department of Clinical Product Development, Institute of Tropical Medicine (NEKKEN), Leading Graduate School Program, and Graduate School of Biomedical Sciences Nagasaki University  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.347.6228.1296"},{"key":"e_1_2_10_3_1","unstructured":"WHO.Middle East respiratory syndrome coronavirus (MERS\u2010CoV). May2017."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12562"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70204-4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306742"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70154-3"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60982-4"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1303729"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211721"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.052910-0"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep01686"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3362"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"e_1_2_10_15_1","unstructured":"Case report guidelines[http:\/\/www.care\u2010statement.org\/]"},{"key":"e_1_2_10_16_1","unstructured":"The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta\u2010analyses[http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp]"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2004.06.014"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.12.011"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005715"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13085"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.12.003"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/M13-2486"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-013-0509-9"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2792"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2014.396"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70920-X"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.11.030"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv085"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.07.026"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2015.4.10243"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066615579858"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.07.001"},{"key":"e_1_2_10_35_1","unstructured":"CDC.Infection prevention\/control and management guidelines for patients with Middle East respiratory syndrome coronavirus (MERS CoV) infection.2014."},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000046"}],"container-title":["Reviews in Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frmv.1977","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.1977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:50:35Z","timestamp":1695473435000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmv.1977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,17]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1002\/rmv.1977"],"URL":"https:\/\/doi.org\/10.1002\/rmv.1977","archive":["Portico"],"relation":{},"ISSN":["1052-9276","1099-1654"],"issn-type":[{"value":"1052-9276","type":"print"},{"value":"1099-1654","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,17]]},"assertion":[{"value":"2018-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1977"}}