{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:14:18Z","timestamp":1783120458720,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T00:00:00Z","timestamp":1531958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of this review was to assess the contribution of herpesviruses in the subgingival oral biofilm in the progression of periodontal and peri\u2010implant diseases in systemically healthy individuals. The literature review was customized to summarize the pertinent information for the following reasons: (1) A systematic review regarding the role of herpesviruses in the etiopathogenesis of periodontal disease has recently been published; and (2) a limited number of studies have assessed the association of herpesviruses with peri\u2010implant diseases. To date, five observational studies have assessed the presence of herpesviruses in the subgingival oral biofilm of individuals with peri\u2010implant diseases. In these studies, dental implants were in place for up to approximately 8\u00a0years. In two studies, human cytomegalovirus (HCMV) was more often isolated from the peri\u2010implant sulci of sites with than without peri\u2010implantitis. In one study, a low prevalence of HCMV compared with Epstein\u2010Barr virus (EBV) was associated with the progression of peri\u2010implantitis. In previous studies, the presence of EBV in the subgingival oral biofilm was associated with the onset of peri\u2010implantitis and peri\u2010implant mucositis, respectively. Major limitations of the studies assessed were the absence of blinding and lack of power analysis for sample size estimation. In conclusion, the presence of herpesviruses in the periodontal and peri\u2010implant subgingival oral biofilm is an indicator of periodontal and peri\u2010implant diseases in systemically healthy individuals; however, further studies with a statistically justified sample\u2010size are needed to understand and refine this association.<\/jats:p>","DOI":"10.1002\/rmv.1996","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T09:54:17Z","timestamp":1531994057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Contribution of herpesviruses in the progression of periodontal and peri\u2010implant diseases in systemically healthy individuals"],"prefix":"10.1002","volume":"28","author":[{"given":"Munerah","family":"Binshabaib","sequence":"first","affiliation":[{"name":"Department of Periodontology, College of Dentistry Princess Nourah Bint Abdulrahman University  Riyadh Saudi 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