{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:45:35Z","timestamp":1788929135603,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T00:00:00Z","timestamp":1534291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    We systematically searched and meta\u2010analyzed the epidemiological characteristics, frequency of clinical signs, and outcomes of dengue\u2010associated hemophagocytic lymphohistiocytosis. Ten electronic databases were searched systematically plus manual search of reference lists to identify relevant articles published until May 2017. The highest number of reported cases were from South\u2010East Asia region (62 cases), followed by Western Pacific region (20 cases), and America (31 cases). The term \u201cdengue hemorrhagic fever\u201d predominated in studies that used the World Health Organization 1997 definition (59.7%), whereas \u201csevere dengue\u201d predominated in studies using the World Health Organization 2009 definition (76.8%)\n                    <jats:bold>.<\/jats:bold>\n                    Among 122 cases, fever, splenomegaly, hepatomegaly, anemia, thrombocytopenia, and serum ferritin \u2265500\u00a0\u03bcg\/L were likely to report by articles representing by large sample size. The pooled proportion of these findings were as follows: fever 97.2%, hepatomegaly 70.2%, splenomegaly 78.4%, thrombocytopenia 90.1%, anemia 76.0%, and serum ferritin \u2265500\u00a0\u03bcg\/L 97.1%\n                    <jats:bold>.<\/jats:bold>\n                    This study highlighted a high case fatality rate (14.6%) and co\u2010infection among dengue hemophagocytic lymphohistiocytosis patients. We suggest that long fever duration, persistent thrombocytopenia, elevated serum ferritin, and lactate dehydrogenase levels could be good diagnostic indicators for dengue\u2010associated hemophagocytic syndrome. Bone marrow aspiration could be used as one criterion for diagnosis but is not obligatory. Further research is needed to examine the possible risk difference for development of hemophagocytic syndrome and to explore potential relationships between specific dengue classifications and dengue\u2010associated hemophagocytic syndrome.\n                  <\/jats:p>","DOI":"10.1002\/rmv.2005","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T07:03:52Z","timestamp":1534316632000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Dengue hemophagocytic syndrome: A systematic review and meta\u2010analysis on epidemiology, clinical signs, outcomes, and risk factors"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8648-483X","authenticated-orcid":false,"given":"Hoang Thi Nam","family":"Giang","sequence":"first","affiliation":[{"name":"The University of Da Nang Da Nang Vietnam"},{"name":"Online Research Club 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