{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:20:47Z","timestamp":1787653247056,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Maternofetal transmission of cytomegalovirus (CMV) is the most common infectious cause of congenital malformation in developed countries. Maternal infection often results from close contact with infected children, and this may occur in day care centres (DCCs).<\/jats:p><jats:p>A systematic review of observational studies was conducted to examine the prevalence of CMV infection among children attending DCCs. Meta\u2010analysis using the random effect model was performed for studies including controls. Sources included PubMed, EMBASE (until August 2018), and references from identified publications. Inclusion criteria were studies reporting CMV infection prevalence among childcare children aged less than 7\u00a0years of age. Controls were children without childcare exposure. CMV infection was defined as viral excretion detected by culture, polymerase chain reaction, or CMV seropositivity.<\/jats:p><jats:p>Twenty\u2010eight publications including 8347 participants met the eligibility criteria. The pooled prevalence of CMV infection among children in childcare from all studies was 32% (95% CI 23\u201041). Within case\u2010controlled studies, prevalence among children attending DCCs was 34% (95% CI 25\u201044), whereas prevalence among those without childcare exposure was 22% (95% CI 15\u201030). Meta\u2010analysis showed a significant association between DCC attendance and CMV infection (odds ratio 2.69, 95% CI 1.68\u20104.30; heterogeneity \u03c7<jats:sup>2<\/jats:sup>\/df\u00a0=\u00a08; I<jats:sup>2<\/jats:sup>\u00a0=\u00a084%,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.00001).<\/jats:p><jats:p>Attendance at DCCs is significantly associated with increased risk of childhood CMV infection. Prevention strategies to reduce risk of CMV infection of pregnant women and children should involve review of DCC exposure and consideration of preventative hygiene strategies.<\/jats:p>","DOI":"10.1002\/rmv.2011","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T06:43:40Z","timestamp":1539240220000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Cytomegalovirus infection in day care centres: A systematic review and meta\u2010analysis of prevalence of infection in children"],"prefix":"10.1002","volume":"29","author":[{"given":"Qing Yu","family":"Zheng","sequence":"first","affiliation":[{"name":"School of Medical Sciences University of New South Wales Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim T.","family":"Huynh","sequence":"additional","affiliation":[{"name":"School of Medical Sciences University of New South Wales Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy J.","family":"van Zuylen","sequence":"additional","affiliation":[{"name":"School of Medical Sciences University of New South Wales Sydney NSW Australia"},{"name":"Serology and Virology Division, NSW Health Pathology, Prince of Wales Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6004-576X","authenticated-orcid":false,"given":"Maria E.","family":"Craig","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales. 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