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Despite its broad availability and the success of it use, the risk stratification based on the D\/R serostatus is not free of limitations since there are a nondepreciable number of patients that are not accurately categorized by this approach. In fact, up to 20% of seropositive SOT recipients, classically considered at intermediate risk, develop episodes of CMV infection and disease after transplantation. Here, we provide an overview of additional donor and recipient factors that may have utility in identifying patients at risk for post\u2010transplant CMV infection. Specifically, we summarize our current understanding regarding the potential use of use CMV\u2010specific T\u2010cell\u2010mediated immunity, neutralizing antibodies and host genetics that may influence the risk of CMV infection and disease. We provide an overview of the benefits and limitations associated with using these immunological factors in risk stratification and propose specific variables that could be analyzed at the pretransplant evaluation to improve the identification of patients with increased individual susceptibility.<\/jats:p>","DOI":"10.1002\/rmv.2017","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T08:35:32Z","timestamp":1540456532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Going beyond serology for stratifying the risk of CMV infection in transplant recipients"],"prefix":"10.1002","volume":"29","author":[{"given":"David","family":"Navarro","sequence":"first","affiliation":[{"name":"Microbiology Service Hospital Cl\u00ednico Universitario, Fundaci\u00f3n INCLIVA  Valencia 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