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Multiple reports have been published encompassing the role of tetherin in the IAV life cycle. To date, nine reports have been published regarding the role of tetherin in the IAV life cycle, with four reports supporting tetherin as an antiviral factor while five other reports suggesting no effect. To this end, this review summarizes the list of viruses currently known to be inhibited by tetherin and describes mechanisms used by viruses to overcome the antiviral potential of tetherin. Further, using IAV as disease model, we provide existing evidence in favor and against tetherin being considered as an antiviral candidate. Subsequent analysis of the experimental procedures across IAV\u2010tetherin published reports revealed that the experimental setup (ie, cell lines, transfection reagents, and multiplicity of infection), strain\u2010specific activity of NS1, and differing roles of NS1 in different cell lines may add up to the contributing factors leading to the discrepancies observed.<\/jats:p>","DOI":"10.1002\/rmv.2036","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T01:31:22Z","timestamp":1548984682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Is tetherin a true antiviral: The influenza a virus controversy"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9805-9315","authenticated-orcid":false,"given":"Anshika","family":"Sharma","sequence":"first","affiliation":[{"name":"School of Science Monash University, Sunway Campus  Bandar Sunway Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3548-4853","authenticated-orcid":false,"given":"Sunil K.","family":"Lal","sequence":"additional","affiliation":[{"name":"School of Science Monash University, Sunway Campus  Bandar Sunway 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