{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:14:18Z","timestamp":1783120458796,"version":"3.54.6"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The pathological role of human herpesviruses (HHVs) (Epstein\u2010Barr virus [EBV], Human cytomegalovirus [CMV], and Herpes simplex virus [HSV]) in peri\u2010implant health needs clarification quantitatively. To determine the weight of evidence for HHVs in patients with peri\u2010implantitis (PI) and substantiate the significance of HHVs in peri\u2010implant inflammation, electronic databases including EMBASE, MEDLINE, Cochrane Oral Health Group Trials Register, and Cochrane Central Register of Controlled Trials were searched from 1964 up to and including November 2018. Meta\u2010analyses were conducted for prevalence of HHVs in PI and healthy controls. Forest plots were generated that recorded risk difference (RD) of outcomes and 95% confidence intervals (CI). Five clinical studies were considered and included. Four clinical studies reported data on EBV while three clinical studies reported data on CMV. Considering the risk of these viruses in PI, significant heterogeneity for CMV (\u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a053.37, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001, I<jats:sup>2<\/jats:sup>\u00a0=\u00a096.25%) and EBV (\u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a014.14, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002, I<jats:sup>2<\/jats:sup>\u00a0=\u00a078.79%) prevalence was noticed between PI and healthy control sites. The overall RD for only EBV (RD\u00a0=\u00a00.20, 95% CI, 0.01\u20100.40, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03) was statistically significant between both groups. Frequencies of the viruses were increased in patients with PI compared with healthy nondiseased sites. However, the findings of the present study should be interpreted with caution because of significant heterogeneity and small number of included studies.<\/jats:p>","DOI":"10.1002\/rmv.2042","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T16:23:59Z","timestamp":1553271839000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Current weight of evidence of viruses associated with peri\u2010implantitis and peri\u2010implant health: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9618-8818","authenticated-orcid":false,"given":"Zohaib","family":"Akram","sequence":"first","affiliation":[{"name":"Department of Oral Restorative and Rehabilitative Sciences, UWA Dental School The University of Western Australia (M512)  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khulud Abdulrahman","family":"Al\u2010Aali","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, College of Dentistry Princess Nourah Bint Abdulrahman University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Alrabiah","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dental Science, College of Dentistry King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal Abdullah","family":"Alonaizan","sequence":"additional","affiliation":[{"name":"Department of Restorative Dental Sciences, College Of Dentistry Imam Abdulrahman Bin Faisal University  Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Abduljabbar","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dental Science, College of Dentistry King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemah","family":"AlAhmari","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Community Dentistry, College of Dentistry King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9253-1989","authenticated-orcid":false,"given":"Fawad","family":"Javed","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahim","family":"Vohra","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dental Science, College of Dentistry King Saud University  Riyadh Saudi 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