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Although many antiviral drugs have been approved for clinical use during the past decade, important issues, such as unsatisfactory efficacy, toxicity, and high cost of drugs, remain unresolved. Glycans are major components of the surfaces of both host cells and most viruses and play critical roles in the steps of viral infection. Marine glycans have more structural diversities than those found in humans. Most importantly, low toxicity and low\u2010cost marine glycans have demonstrated potent antiviral activities through multiple molecular mechanisms. As a result, a series of marine glycan\u2013derived agents are undergoing preclinical and clinical trials. This review discusses the recent progress in research on the marine glycan\u2013based antiviral agents in clinical trials, relating to their structural features and clinical applications. In addition, molecular mechanisms of marine glycans involved in viral infection and novel strategies used in glycan\u2010based drug development are critically reviewed and discussed.<\/jats:p>","DOI":"10.1002\/rmv.2043","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T14:29:29Z","timestamp":1554301769000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Marine glycan\u2013based antiviral agents in clinical or preclinical trials"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8804-0629","authenticated-orcid":false,"given":"Cui","family":"Hao","sequence":"first","affiliation":[{"name":"Systems Biology and Medicine Center for Complex Diseases Affiliated Hospital of Qingdao University  Qingdao PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangli","family":"Yu","sequence":"additional","affiliation":[{"name":"Key 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