{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:22:09Z","timestamp":1790702529127,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Dengue virus is known to modulate host cell lipid metabolism in order to promote efficient viral replication. Recent studies have focused on circulating lipids as potential biomarkers of dengue severity; however, the results obtained so far lack the consistency to establish a definite relationship between the two. Therefore, in the present study, we investigated serum lipids as potential biomarkers of dengue severity by conducting a meta\u2010analysis of the currently available clinical data. Nine studies that evaluated 1,953 patients were included in the review, many of which were cross\u2010sectional (44.4%) and conducted in Asian countries (55.5%). These studies observed the presence of lipids in serum samples (77%) of patients in the acute phase of the disease (88.8%). Circulating total\u2010cholesterol (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) and LDL (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) levels, but not HDL (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.07), VLDL (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.9) and triglyceride (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.57) levels, were inversely and significantly correlated with dengue severity. Total cholesterol (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a0.001) and LDL (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) were also useful in determining the risk of hypovolemic shock in patients with severe dengue. Subgroup analysis showed that factors, such as design (cross\u2010sectional vs cohort), racial\u2010ethnic differences (Asian vs Latin Americans), and age range (children vs adult) influenced the correlation and also contributed to the high level of heterogeneity in the studies. Our meta\u2010analysis demonstrates that total\u2010cholesterol and LDL\u2010cholesterol levels should be explored as routine laboratory markers for dengue severity, as they will help in employing an appropriate patient therapy, and thus optimize the use of available resources.<\/jats:p>","DOI":"10.1002\/rmv.2056","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T04:59:48Z","timestamp":1559883588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Serum lipid profile as a predictor of dengue severity: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8946-9363","authenticated-orcid":false,"given":"William Gustavo","family":"Lima","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Radiois\u00f3topos, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de farm\u00e1cia, Campus Pampulha Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayara Alves","family":"Souza","sequence":"additional","affiliation":[{"name":"Escola de Enfermagem, Campus Centro\u2010oeste Dona Lindu Universidade Federal de S\u00e3o Jo\u00e3o Del\u2010rei Divin\u00f3polis MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Od\u00edlia Antunes","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Radiois\u00f3topos, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de farm\u00e1cia, Campus Pampulha Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valbert Nascimento","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Radiois\u00f3topos, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de farm\u00e1cia, Campus Pampulha Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella Piassi","family":"God\u00f3i","sequence":"additional","affiliation":[{"name":"Instituto de Sa\u00fade e Estudos Biol\u00f3gicos Universidade Federal do Sul e Sudeste do Par\u00e1 Marab\u00e1 Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-018-3375-7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41426-018-0168-0"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2149\/tmh.2011-S04"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12060"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2018.05.001"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/2231-0762.175416"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/088282403763635465"},{"key":"e_1_2_11_9_1","unstructured":"World Health Organization.Dengue Haemorrhagic Fever: Diagnosis Treatment Prevention and Control. 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