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Therefore, the understanding of the anti\u2010flavivirus humoral immune response is fundamental to future studies on flavivirus pathogenesis and the design of anti\u2010flavivirus therapeutics. This review aims to provide an overview of the current understanding of the function and involvement of flavivirus proteins in the humoral immune response as well as the ability of the anti\u2010envelope (anti\u2010E) antibodies to interfere (neutralizing antibodies) or not (non\u2010neutralizing antibodies) with viral infection, and how they can, in some circumstances enhance dengue virus infection on Fc gamma receptor (Fc\u03b3R) bearing cells through a mechanism known as antibody\u2010dependent enhancement (ADE). Thus, the dual role of the antibodies against E protein poses a formidable challenge for vaccine development. 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