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Current therapeutic options are limited and there is no registered and\/or definite treatment or vaccine for this disease or the causative infection, severe acute respiratory coronavirus 2 syndrome (SARS\u2010CoV\u20102). Angiotensin\u2010converting enzyme 2 (ACE2), a part of the renin\u2010angiotensin system (RAS), serves as the major entry point into cells for SARS\u2010CoV\u20102 which attaches to human ACE2, thereby reducing the expression of ACE2 and causing lung injury and pneumonia. Vitamin D, a fat\u2010soluble\u2010vitamin, is a negative endocrine RAS modulator and inhibits renin expression and generation. It can induce ACE2\/Ang\u2010(1\u20107)\/MasR axis activity and inhibits renin and the ACE\/Ang II\/AT1R axis, thereby increasing expression and concentration of ACE2, MasR and Ang\u2010(1\u20107) and having a potential protective role against acute lung injury (ALI)\/acute respiratory distress syndrome (ARDS). Therefore, targeting the unbalanced RAS and ACE2 down\u2010regulation with vitamin D in SARS\u2010CoV\u20102 infection is a potential therapeutic approach to combat COVID\u201019 and induced ARDS.<\/jats:p>","DOI":"10.1002\/rmv.2119","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T12:49:59Z","timestamp":1593089399000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["A brief review of interplay between vitamin D and angiotensin\u2010converting enzyme 2: Implications for a potential treatment for <scp>COVID<\/scp>\u201019"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0176-5438","authenticated-orcid":false,"given":"Aida","family":"Malek Mahdavi","sequence":"first","affiliation":[{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences  Tabriz 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