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At what range of temperatures are common respiratory viruses sensitive? What is the mechanism for their temperature sensitivity? What is the range of temperature along the human airway? What is it that makes respiratory viruses such successful parasites of the human airway? What is the role of temperature sensitivity in respiratory zoonoses? A definition of temperature sensitivity is proposed, as \u201cthe property of a virus to replicate poorly or not at all, at the normal body temperature of the host (restrictive temperature), but to replicate well at the lower temperatures found in the upper airway of the host (permissive temperature).\u201d Temperature sensitivity may influence the success of a respiratory virus in several ways. Firstly; by restricting the infection to the upper airways and reducing the chance of systemic infection that may reduce host mobility and increase mortality, and thus limit the spread of the virus. Secondly; by causing a mild upper airway illness with a limited immune response compared to systemic infection, which means that persistent herd immunity does not develop to the same extent as with systemic infections, and re\u2010infection may occur later. Thirdly; infection of the upper airway triggers local reflex rhinorrhea, coughing and sneezing which aid the exit of the virus from the host and the spread of infection in the community.<\/jats:p>","DOI":"10.1002\/rmv.2153","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T07:49:25Z","timestamp":1597045765000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Why is temperature sensitivity important for the success of common respiratory viruses?"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9492-2062","authenticated-orcid":false,"given":"Ronald","family":"Eccles","sequence":"first","affiliation":[{"name":"Emeritus Professor, Cardiff School of Biosciences Cardiff University  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,10]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.05.00009503"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62226-X"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2015.11.005"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197901183000309"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200202000-00017"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.03.025"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11100928"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1526-0542(03)00031-9"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00045-07"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2020.05.005"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2012.05282.x"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02291-09"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/1.3.413"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.23.3.109-124.1959"},{"key":"e_1_2_13_16_1","first-page":"446","article-title":"The relation of air temperature to certain plant diseases","volume":"11","author":"Johnson J","year":"1921","journal-title":"Phytopathology"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.py.22.090184.000331"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/v10100560"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(60)90168-9"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a121171"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-016-0474-9"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200004000-00021"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5223.393"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.141.3576.152"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199905)58:1<100::AID-JMV16>3.0.CO;2-D"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1993.tb00316.x"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25640-0"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.57.4.933"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.23.4.800-802.1986"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12446"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/bp025585a"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12542"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.79925-0"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/v8010016"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.10.012"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.41.2.353-359.1982"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(75)90224-X"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.52.608.381"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(80)90241-X"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-3-58"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00589-15"},{"key":"e_1_2_13_42_1","article-title":"Modification of inspired air. 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