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In particular, this pandemic has further exacerbated the burden in tropical and subtropical regions of the world, where dengue fever, caused by dengue virus (DENV), is already endemic to the population. The similar clinical manifestations shared by Covid\u201019 and dengue fever have raised concerns, especially in dengue\u2010endemic countries with limited resources, leading to diagnostic challenges. In addition, cross\u2010reactivity of the immune responses in these infections is an emerging concern, as pre\u2010existing DENV\u2010antibodies might potentially affect Covid\u201019 through antibody\u2010dependent enhancement. In this review article, we aimed to raise the issue of Covid\u201019 and dengue fever misdiagnosis, not only in a clinical setting but also with regards to cross\u2010reactivity between SARS\u2010CoV\u20102 and DENV antibodies. 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