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It is an enveloped, positive\u2010sense, single\u2010stranded RNA virus, which encodes a single polyprotein that is cleaved into 10 individual proteins. In 2015, the Zika\u2010epidemic in Brazil was marked mainly by the exponential growth of microcephaly cases and other congenital defects. With regard to host\u2013pathogen relationships, understanding the role of the immune response in the pathogenesis ZIKV infection is challenging. The innate immune response is the first\u2010line immunological defence, in which pathogen\u2010associated molecular patterns are recognized by pattern\u2010recognition receptors that trigger macrophages, dendritic cells, natural killer cells and endothelial cells to produce several mediators, which modulate viral replication and immune evasion. 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