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Declared a pandemic on March 11 by World Health Organization, the disease caused by SARS\u2010CoV\u20102 infection, called coronavirus disease 2019 (COVID\u201019), has become a global public health crisis that challenged all national healthcare systems. This review summarized the current knowledge about virologic and pathogenic characteristics of SARS\u2010CoV\u20102 with emphasis on potential immunomodulatory mechanism and drug development. With multiple emerging technologies and cross\u2010disciplinary approaches proving to be crucial in our global response against COVID\u201019, the application of PROteolysis TArgeting Chimeras strategy, CRISPR\u2010Cas9 gene editing technology, and Single\u2010Nucleotide\u2010Specific Programmable Riboregulators technology in developing antiviral drugs and detecting infectious diseases are proposed here. We also discussed the available but still limited epidemiology of COVID\u201019 as well as the ongoing efforts on vaccine development. 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