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Blood clotting disorders and acute respiratory failure have surfaced as the major complications among the severe cases of coronavirus disease 2019 (COVID\u201019) caused by SARS\u2010CoV\u20102 infection. Remarkably, more than 70% of deaths related to COVID\u201019 are attributed to clotting\u2010associated complications such as pulmonary embolism, strokes and multi\u2010organ failure. These vascular complications have been confirmed by autopsy. This study summarizes the current understanding and explains the possible mechanisms of the blood clotting disorder, emphasizing the role of (1) hypoxia\u2010related activation of coagulation factors like tissue factor, a significant player in triggering coagulation cascade, (2) cytokine storm and activation of neutrophils and the release of neutrophil extracellular traps and (3) immobility and ICU related risk factors.<\/jats:p>","DOI":"10.1002\/rmv.2177","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T22:30:46Z","timestamp":1602023446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Clotting disorder in severe acute respiratory syndrome coronavirus 2"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5856-5328","authenticated-orcid":false,"given":"Sujit","family":"Pujhari","sequence":"first","affiliation":[{"name":"Department of 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