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To prevent the worldwide spread of this highly pathogenic virus, development of an effective and safe vaccine is urgently needed. The SARS\u2010CoV\u20102 and SARS\u2010CoV share a high degree of genetic and pathologic identity and share safety and immune\u2010enhancement concerns regarding vaccine development. Prior animal studies with first generation (whole virus\u2010based) preparations of SARS\u2010CoV vaccines (inactivated and attenuated vaccine modalities) indicated the possibility of increased infectivity or eosinophilic infiltration by immunization. Therefore, development of second and third generation safer vaccines (by using modern vaccine platforms) is actively sought for this viral infection. The spike (S) protein of SARS\u2010CoVs is the main determinant of cell entry and tropism and is responsible for facilitating zoonosis into humans and sustained person\u2010to\u2010person transmission. Furthermore, \u2018S\u2019 protein contains multiple neutralizing epitopes that play an essential role in the induction of neutralizing antibodies (nAbs) and protective immunity. Moreover, T\u2010cell responses against the SARS\u2010CoV\u20102 \u2018S\u2019 protein have also been characterized that correlate to the IgG and IgA antibody titres in Covid\u201019 patients. Thus, S protein is an obvious candidate antigen for inclusion into vaccine platforms against SARS\u2010CoV\u20102 viral infection. This manuscript reviews different characteristics of S protein, its potency and \u2018state of the art\u2019 of the vaccine development strategies and platforms using this antigen, for construction of a safe and effective SARS\u2010CoV\u20102 vaccine.<\/jats:p>","DOI":"10.1002\/rmv.2183","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T19:30:52Z","timestamp":1602790252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Severe acute respiratory syndrome\u2010coronavirus\u20102 spike (S) protein based vaccine candidates: State of the art and future prospects"],"prefix":"10.1002","volume":"31","author":[{"given":"Arash","family":"Arashkia","sequence":"first","affiliation":[{"name":"Department of Molecular Virology Pasteur Institute of Iran  Tehran 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