{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T14:48:40Z","timestamp":1775486920528,"version":"3.50.1"},"reference-count":109,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008982","name":"Qatar National Research Fund","doi-asserted-by":"publisher","award":["RRC\u20102\u2010032"],"award-info":[{"award-number":["RRC\u20102\u2010032"]}],"id":[{"id":"10.13039\/100008982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The current severe acute respiratory syndrome coronavirus\u20102 (SARS\u2010CoV\u20102) outbreak has been rapidly spreading worldwide, causing serious global concern. The role that animal hosts play in disease transmission is still understudied and researchers wish to find suitable animal models for fundamental research and drug discovery. In this systematic review, we aimed to compile and discuss all articles that describe experimental or natural infections with SARS\u2010CoV\u20102, from the initial discovery of the virus in December 2019 through to October 2020. We systematically searched four databases (Scopus, PubMed, Science Direct and Web of Science). The following data were extracted from the included studies: type of infection (natural or experimental), age, sample numbers, dose, route of inoculation, viral replication, detection method, clinical symptoms and transmission. Fifty\u2010four studies were included, of which 34 were conducted on animal reservoirs (naturally or experimentally infected), and 20 involved models for testing vaccines and therapeutics. Our search revealed that <jats:italic>Rousettus aegyptiacus<\/jats:italic> (fruit bats), pangolins, felines, mink, ferrets and rabbits were all susceptible to SARS\u2010CoV\u20102, while dogs were weakly susceptible and pigs, poultry, and tree shrews were not. In addition, virus replication in mice, mink, hamsters and ferrets resembled subclinical human infection, so these animals might serve as useful models for future studies to evaluate vaccines or antiviral agents and to study host\u2010pathogen interactions. Our review comprehensively summarized current evidence on SARS\u2010CoV\u20102 infection in animals and their usefulness as models for studying vaccines and antiviral drugs. Our findings may direct future studies for vaccine development, antiviral drugs and therapeutic agents to manage SARS\u2010CoV\u20102\u2010caused diseases.<\/jats:p>","DOI":"10.1002\/rmv.2196","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T22:47:57Z","timestamp":1605739677000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Severe acute respiratory syndrome coronavirus\u20102 natural animal reservoirs and experimental models: systematic review"],"prefix":"10.1002","volume":"31","author":[{"given":"Salma","family":"Younes","sequence":"first","affiliation":[{"name":"Biomedical Research Center Member of QU Health Qatar University  Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadin","family":"Younes","sequence":"additional","affiliation":[{"name":"Biomedical Research Center Member of QU Health Qatar University  Doha 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