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PubMed and Google scholar databases were used to collect eligible publications until 8 December 2020. Meta\u2010analysis used Mantel\u2013Haenszel risk ratio (RR) with 95% confidence interval (CI) and pooled analysis for individual patient data with inverse variance weighted average. The study is registered at PROSPERO with the number of CRD4200270579. Forty\u2010four studies with 36,716 participants were included in the pooled analysis and 20 studies in the meta\u2010analysis. Meta\u2010analysis showed reduction of mortality (RR 0.57, 95% CI [0.43, 0.76], <jats:italic>z<\/jats:italic>\u00a0=\u00a03.86 [<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001], <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a044% [<jats:italic>p<\/jats:italic>\u00a0=\u00a00.03]) and higher number of discharged patients (RR 2.53, 95% CI [1.72, 3.72], <jats:italic>z<\/jats:italic>\u00a0=\u00a04.70 [<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001], <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a03% [<jats:italic>p<\/jats:italic>\u00a0=\u00a00.39]) in patients receiving CPT compared to standard care alone. A possible mechanism of action is prompt reduction in viral titre. Serious transfusion\u2010related adverse events were reported to be less than 1% of cases, suggesting the overall safety of CPT; nevertheless, the number of patients participating in the studies was still limited. It is also important to notice that in all the studies, the majority of patients were also given other medications, such as antivirals, antibiotics and corticosteroid; furthermore, randomized controlled studies involving more patients and in combination with other treatment modalities are urgently needed.<\/jats:p>","DOI":"10.1002\/rmv.2225","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T22:52:51Z","timestamp":1614120771000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Current views on the potentials of convalescent plasma therapy (CPT) as Coronavirus disease 2019 (COVID\u201019) treatment: A systematic review and meta\u2010analysis based on recent studies and previous respiratory pandemics"],"prefix":"10.1002","volume":"31","author":[{"given":"Jenifer Kiem","family":"Aviani","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of 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