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Cells in the oral cavity express viral entry receptor angiotensin\u2010converting enzyme 2 that allows viral replication and may cause tissue inflammation and destruction. Recent studies have reported that Covid\u201019 patients present oral manifestations with multiple clinical aspects. In this review, we aim to summarise main signs and symptoms of Covid\u201019 in the oral cavity, its possible association with oral diseases, and the plausible underlying mechanisms of hyperinflammation reflecting crosstalk between Covid\u201019 and oral diseases. Ulcers, blisters, necrotising gingivitis, opportunistic coinfections, salivary gland alterations, white and erythematous plaques and gustatory dysfunction were the most reported clinical oral manifestations in patients with Covid\u201019. In general, the lesions appear concomitant with the loss of smell and taste. Multiple reports show evidences of necrotic\/ulcerative gingiva, oral blisters and hypergrowth of opportunistic oral pathogens. SARS\u2010CoV\u20102 exhibits tropism for endothelial cells and Covid\u201019\u2010mediated endotheliitis can not only promote inflammation in oral tissues but can also facilitate virus spread. In addition, elevated levels of proinflammatory mediators in patients with Covid\u201019 and oral infectious disease can impair tissue homeostasis and cause delayed disease resolution. This suggests potential crosstalk of immune\u2010mediated pathways underlying pathogenesis. Interestingly, few reports suggest recurrent herpetic lesions and higher bacterial growth in Covid\u201019 subjects, indicating SARS\u2010CoV\u20102 and oral virus\/bacteria interaction. Larger cohort studies comparing SARS\u2010CoV\u20102 negative and positive subjects will reveal oral manifestation of the virus on oral health and its role in exacerbating oral infection.<\/jats:p>","DOI":"10.1002\/rmv.2226","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T11:39:54Z","timestamp":1614598794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Covid\u201019 and oral diseases: Crosstalk, synergy or association?"],"prefix":"10.1002","volume":"31","author":[{"given":"Daniela A.","family":"Brandini","sequence":"first","affiliation":[{"name":"Department of Diagnosis and Surgery School of Dentistry S\u00e3o Paulo State University (UNESP)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline S.","family":"Takamiya","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery School of Dentistry 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