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The increasing global health and economic burden of SARS\u2010CoV\u20102 has necessitated urgent investigations into the pathogenesis of disease and development of therapeutic and vaccination regimens. Human trials of vaccine and antiviral candidates have been undertaken, but basic pathogenetic studies are still required to inform these trials. Gaps in understanding of cellular infection by, and immunity to, SARS\u2010CoV\u20102 mean additional models are required to assist in improved design of these therapeutics. Human organoids are three\u2010dimensional models that contain multiple cell types and mimic human organs in ex vivo culture conditions. The SARS\u2010CoV\u20102 virus has been implicated in causing not only respiratory injury but also injury to other organs such as the brain, liver and kidneys. Consequently, a variety of different organoid models have been employed to investigate the pathogenic mechanisms of disease due to SARS\u2010CoV\u20102. Data on these models have not been systematically assembled. In this review, we highlight key findings from studies that have utilised different human organoid types to investigate the expression of SARS\u2010CoV\u20102 receptors, permissiveness, immune response, dysregulation of cellular functions, and potential antiviral therapeutics.<\/jats:p>","DOI":"10.1002\/rmv.2227","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T08:03:28Z","timestamp":1616659408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Review of studies of severe acute respiratory syndrome related coronavirus\u20132 pathogenesis in human organoid models"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5926-7082","authenticated-orcid":false,"given":"Ece","family":"Egilmezer","sequence":"first","affiliation":[{"name":"Serology and Virology Division NSW Health Pathology Prince of Wales Hospital  Sydney Australia"},{"name":"School of Medical Sciences University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0988-7827","authenticated-orcid":false,"given":"William D","family":"Rawlinson","sequence":"additional","affiliation":[{"name":"Serology and Virology Division NSW Health Pathology Prince of Wales Hospital  Sydney Australia"},{"name":"School of Medical Sciences University of New South Wales  Sydney Australia"},{"name":"School of Women's and Children's Health University of New South Wales  Sydney Australia"},{"name":"School of Biotechnology and Biomolecular Sciences University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30251-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0118-9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa626"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-virology-012420-022445"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.0757"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/traa025"},{"key":"e_1_2_10_8_1","first-page":"55","volume-title":"Clinical Characteristics and Differential Clinical Diagnosis of Novel Coronavirus Disease 2019 (COVID\u201019). 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