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HPV\u2010related cancers have been related to oxidative stress (OS), where OS has a significant role in cancer development and maintenance. Surgical resection is the treatment of choice for localised HPV\u2010related cancers; however, these malignancies commonly progress to metastasis. In advanced stages, systemic therapies are the best option against HPV\u2010related cancers. These therapies include cytokine therapy or a combination of tyrosine kinase inhibitors with immunotherapies. Nevertheless, these strategies are still insufficient. Cell redox\u2010sensitive signalling pathways have been poorly studied, although they have been associated with the development and maintenance of HPV\u2010related cancers. In this review, we analyse the known alterations of the following redox\u2010sensitive molecules and signalling pathways by HR\u2010HPV in HPV\u2010related cancers: MAPKs, Akt\/TSC2\/mTORC1, Wnt\/\u03b2\u2010Cat, NFkB\/IkB\/NOX2, HIF\/VHL\/VEGF and mitochondrial signalling pathways as potential targets for redox therapy.<\/jats:p>","DOI":"10.1002\/rmv.2230","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T05:38:46Z","timestamp":1615527526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Redox\u2010sensitive signalling pathways regulated by human papillomavirus in HPV\u2010related cancers"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0077-5079","authenticated-orcid":false,"given":"Alfredo","family":"Cruz\u2010Gregorio","sequence":"first","affiliation":[{"name":"Laboratorio F\u2010225 Departamento de Biolog\u00eda Facultad de 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