{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T01:23:28Z","timestamp":1782264208459,"version":"3.54.5"},"reference-count":222,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Infectious diseases occur worldwide with great frequency in both adults and children, causing 350,000 deaths in 2017, according to the latest World Health Organization reports. Both infections and their treatments trigger mitochondrial interactions at multiple levels: (i) incorporation of damaged or mutated proteins into the complexes of the electron transport chain; (ii) impact on mitochondrial genome (depletion, deletions and point mutations) and mitochondrial dynamics (fusion and fission); (iii) membrane potential impairment; (iv) apoptotic regulation; and (v) generation of reactive oxygen species, among others. Such alterations may result in serious adverse clinical events with considerable impact on the quality of life of the children and could even cause death. Herein, we use a systematic review to explore the association between mitochondrial alterations in paediatric infections including human immunodeficiency virus, cytomegalovirus, herpes viruses, various forms of hepatitis, adenovirus, T\u2010cell lymphotropic virus and influenza. We analyse how these paediatric viral infectious processes may cause mitochondrial deterioration in this especially vulnerable population, with consideration for the principal aspects of research and diagnosis leading to improved disease understanding, management and surveillance.<\/jats:p>","DOI":"10.1002\/rmv.2232","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T05:05:12Z","timestamp":1617253512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mitochondrial changes associated with viral infectious diseases in the paediatric population"],"prefix":"10.1002","volume":"31","author":[{"given":"Sonia","family":"Romero\u2010Cordero","sequence":"first","affiliation":[{"name":"Faculty of Medicine Pompeu Fabra University  Barcelona Spain"},{"name":"Faculty of Medicine Universitat Aut\u00f2noma de Barcelona  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Noguera\u2010Julian","sequence":"additional","affiliation":[{"name":"Malalties Infeccioses i Resposta Inflamat\u00f2ria Sist\u00e8mica en Pediatria Unitat d\u00b4Infeccions Servei de Pediatria Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u  Barcelona Spain"},{"name":"Departament de Pediatria Universitat de Barcelona  Barcelona Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica, CIBERESP (ISCIII)  Madrid Spain"},{"name":"Red de Investigaci\u00f3n Translacional en Infectolog\u00eda Pedi\u00e1trica RITIP  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Cardellach","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences Muscle Research and Mitochondrial Function Laboratory Cellex\u2010IDIBAPS University of Barcelona  Barcelona Spain"},{"name":"CIBER de Enfermedades Raras CIBERER (ISCIII)  Madrid Spain"},{"name":"Internal Medicine Department Hospital Cl\u00ednic of Barcelona (HCB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e0udia","family":"Fortuny","sequence":"additional","affiliation":[{"name":"Malalties Infeccioses i Resposta Inflamat\u00f2ria Sist\u00e8mica en Pediatria Unitat d\u00b4Infeccions Servei de Pediatria Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u  Barcelona Spain"},{"name":"Departament de Pediatria Universitat de Barcelona  Barcelona Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica, CIBERESP (ISCIII)  Madrid Spain"},{"name":"Red de Investigaci\u00f3n Translacional en Infectolog\u00eda Pedi\u00e1trica RITIP  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6848-7407","authenticated-orcid":false,"given":"Constanza","family":"Mor\u00e9n","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences Muscle Research and Mitochondrial Function Laboratory Cellex\u2010IDIBAPS University of Barcelona  Barcelona Spain"},{"name":"CIBER de Enfermedades Raras CIBERER (ISCIII)  Madrid Spain"},{"name":"Internal Medicine Department Hospital Cl\u00ednic of Barcelona (HCB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201506131"},{"key":"e_1_2_9_3_1","volume-title":"Mitochondrial Funcionalism in HIV\u2010Infected Children Receiving Antiretroviral Therapy","author":"Mor\u00e9n C","year":"2012"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2018.06.002"},{"key":"e_1_2_9_5_1","volume-title":"Mitochondria","author":"Scheffler IE","year":"2017"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2016.07.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/738794"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.117.300262"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-802395-2.00010-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.12.025"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470191774"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2017"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2009.0062"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.12.029"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.10.017"},{"key":"e_1_2_9_16_1","volume-title":"Reverse Transcribing DNA and RNA Viruses 2011, ICTV 9th Report","author":"ICTV"},{"key":"e_1_2_9_17_1","volume-title":"Tipos de VIH: el VIH\u20101 y el VIH\u20102, subtipos y cuasiespecies","year":"2020"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/MR.57.1.183-289.1993"},{"key":"e_1_2_9_19_1","article-title":"Is breastfeeding for HIV\u2010positive mothers now recommendable?","volume":"148","author":"Gamell A","year":"2018","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.midw.2018.01.018"},{"key":"e_1_2_9_21_1","volume-title":"Documento de consenso para el seguimiento de la infecci\u00f3n por el VIH en relaci\u00f3n con la reproducci\u00f3n, embarazo, parto y profilaxis de la transmisi\u00f3n vertical del ni\u00f1o expuesto","author":"De los Santos FG","year":"2018"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2010.0204"},{"key":"e_1_2_9_23_1","volume-title":"Scientists Unveil Piece of HIV Protein that May Be Key to AIDS Vaccine Development","author":"National Institute of Health","year":"2007"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2011.08.001"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb600131q"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb07030.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200002)30:2<661::AID-IMMU661>3.0.CO;2-L"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf683"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1998.6958"},{"key":"e_1_2_9_30_1","article-title":"Biolog\u00eda celular y molecular del virus de inmunodeficiencia humana (VIH)","volume":"52","author":"Santana A DC","year":"2003","journal-title":"Rev Diagn Biol"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205313200"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00756-09"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.1.33"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1086\/314798"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/v4113020"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1993.9.761"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2019.04.003"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/312763a0"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010126"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-016-0424-9"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000894"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803263381301"},{"key":"e_1_2_9_43_1","volume-title":"Epidemiology","author":"ONUSIDA","year":"2018"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199509000-00001"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.126.6.1353"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012035"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb05609.x"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.143.12.3956"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401374"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.2741\/1268"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2010.05.005"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003731"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450116666150531162212"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00396.x"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200002)47:2<186::AID-ANA8>3.0.CO;2-3"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-017-9776-z"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1086\/427949"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617288114"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00993-18"},{"issue":"9","key":"e_1_2_9_60_1","first-page":"2578","article-title":"Imbalance in mitochondrial dynamics and apoptosis in pregnancies among HIV\u2010infected women on HAART with obstetric complications","volume":"72","author":"Guitart\u2010Mampel M","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.77.3.158"},{"key":"e_1_2_9_62_1","volume-title":"Prevenci\u00f3n e Investigaci\u00f3n del VIH\/SIDA","author":"InfoSIDA, Informaci\u00f3n Sobre Tratamiento"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2014.64"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(00)90004-3"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1680"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057223"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc2162"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001647"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181799662"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.8.2687-2691.2002"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv098"},{"issue":"4","key":"e_1_2_9_72_1","first-page":"419","article-title":"Resistance profile of children and adolescents infected with HIV\u20101 in urban areas in Togo","volume":"28","author":"Takassi OE","year":"2018","journal-title":"Med Sante Trop"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2019.100239"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piz038"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/493413"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21484"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-019-0663-z"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200565080-00007"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000145476.97866.60"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2009.0151"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0213-005X(08)76560-1"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(14)70027-X"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001808"},{"key":"e_1_2_9_84_1","volume-title":"LiverTox: Clinical and Research Information on Drug\u2010Induced Liver Injury","year":"2012"},{"key":"e_1_2_9_85_1","volume-title":"Uso de elvitegravir\/cobicistat durante el embarazo: riesgo de fracaso terap\u00e9utico y transmisi\u00f3n de la infecci\u00f3n vih de madre a hijo. Aemps","year":"2019"},{"key":"e_1_2_9_86_1","first-page":"266","article-title":"Mitochondrial dynamics and metabolic regulation in cardiac and skeletal muscle","volume":"129","author":"Abel ED","year":"2018","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1947"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1086\/507645"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000486"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00893-07"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2005.11.007"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000663"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-013-0227-1"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200219666171207121313"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200308150-00006"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002628"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-014-1477-5"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.14.1.13"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2016.04.007"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.882323"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13181-013-0325-8"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2006.02.001"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0955"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1201"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182253c54"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740331003627458"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12693"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000138982.68106.6c"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00434-08"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0242-6498(05)80134-8"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2012.0354"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1806"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1177\/135965350901400309"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31827030a6"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2003.tb00014.x"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-012-0120-3"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21045"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001760"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2034"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01183-19"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0716-10182016000100007"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-017-0358-8"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.611"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1744"},{"key":"e_1_2_9_125_1","volume-title":"Ctomegalovirus","author":"Dioverti M. R. R."},{"key":"e_1_2_9_126_1","volume-title":"Documento de consenso de la Sociedad Espa\u00f1ola de Infectolog\u00eda Pedi\u00e1trica sobre el diagn\u00f3stico y el tratamiento de la infecci\u00f3n cong\u00e9nita por citomegalovirus","author":"Asociaci\u00f3n Espa\u00f1ola de Pediatr\u00eda","year":"2009"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2009.07.029"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00029-16"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1306.06023"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1186\/2042-4280-4-2"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00145-13"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00023-08"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.3390\/v6041612"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310214"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404599"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2016.1173540"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2012.06.001"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-5229.152772"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.199"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.12.010"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(03)00192-6"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1814"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400878"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-018-3890-y"},{"key":"e_1_2_9_145_1","volume-title":"Virus del herpes simple","author":"Organizaci\u00f3n Mundial de la Salud","year":"2020"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.21.11307"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.4321\/S0213-12852011000100002"},{"key":"e_1_2_9_148_1","volume-title":"Infecci\u00f3n neonatal por virus herpes simple (HSV). Manual MSN. Versi\u00f3n para profesionales"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-3233"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.192"},{"key":"e_1_2_9_151_1","volume-title":"Cold Sores in Children: About the Herpes Simplex Virus","author":"American Academy of Pediatrics","year":"2017"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152612798994948"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81949-0"},{"key":"e_1_2_9_154_1","volume-title":"Aciclovir","author":"Vademecum","year":"2016"},{"key":"e_1_2_9_155_1","volume-title":"Famciclovir","author":"Vademecum","year":"2016"},{"key":"e_1_2_9_156_1","volume-title":"Valaciclovir","author":"Vademecum","year":"2016"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001451"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003509"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01508-09"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21638"},{"issue":"9","key":"e_1_2_9_161_1","article-title":"Modeling herpes simplex virus 1 infections in human central nervous system neuronal cells using two\u2010 and three\u2010dimensional cultures derived from induced pluripotent stem cells","volume":"93","author":"D'Aiuto L","year":"2019","journal-title":"J Virol"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-53168-7_3"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14156"},{"key":"e_1_2_9_164_1","volume-title":"Hepatitis","author":"Bravo J","year":"2017"},{"issue":"3","key":"e_1_2_9_165_1","first-page":"198","article-title":"Hepatitis agudas","volume":"19","author":"Marug\u00e1n JM","year":"2015","journal-title":"Pediatr Integr"},{"issue":"261","key":"e_1_2_9_166_1","first-page":"73","article-title":"Hepatitis virales en la infancia","volume":"58","author":"Galoppoa M","year":"2016","journal-title":"Rev Hosp Ni\u00f1os (B. Aires)"},{"key":"e_1_2_9_167_1","volume-title":"Hepatitis E","author":"World Health Organization","year":"2019"},{"key":"e_1_2_9_168_1","volume-title":"Hepatitis D","author":"World Health Organization","year":"2019"},{"key":"e_1_2_9_169_1","volume-title":"Hepatitis B","author":"World Health Organization","year":"2019"},{"key":"e_1_2_9_170_1","volume-title":"Hepatitis A","author":"World Health Organization","year":"2019"},{"key":"e_1_2_9_171_1","volume-title":"Hepatitis C","author":"World Health Organization","year":"2019"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.4103\/0256-4947.81538"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.3390\/v9080230"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00154-08"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.20517\/2394-5079.2016.05"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12020175"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.37973"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003722"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506412200"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.30983"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2009.01238.x"},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04591.x"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i10.2624"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2017-0321"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800620R"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1885"},{"key":"e_1_2_9_187_1","article-title":"Direct\u2010acting antivirals for chronic hepatitis C","volume":"9","author":"Jakobsen JC","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2009.01159.x"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00057-13"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408360290795439"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.06.078"},{"key":"e_1_2_9_192_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02569"},{"issue":"6","key":"e_1_2_9_193_1","first-page":"741","article-title":"Electron microscopic alterations in intermediate hepatocyte\u2010like cells in children with chronic hepatitis B: the first report in pediatric patients","volume":"22","author":"Lotowska JM","year":"2010","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"e_1_2_9_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.07.018"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8040290"},{"key":"e_1_2_9_196_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.674861"},{"key":"e_1_2_9_197_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46344"},{"issue":"10","key":"e_1_2_9_198_1","doi-asserted-by":"crossref","first-page":"1S45","DOI":"10.1016\/S0755-4982(05)73409-6","article-title":"Utilisation des antir\u00e9troviraux chez le patient cirrhotique infect\u00e9 par le VIH","volume":"34","author":"Salmon\u2010C\u00e9ron D","year":"2005","journal-title":"Presse Med"},{"key":"e_1_2_9_199_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i38.6212"},{"key":"e_1_2_9_200_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"e_1_2_9_201_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1584923"},{"key":"e_1_2_9_202_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.65.6.2968-2978.1991"},{"key":"e_1_2_9_203_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209040"},{"key":"e_1_2_9_204_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208836"},{"key":"e_1_2_9_205_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.9.2109"},{"key":"e_1_2_9_206_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01499-16"},{"key":"e_1_2_9_207_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13904"},{"key":"e_1_2_9_208_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-014-0095-1"},{"key":"e_1_2_9_209_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2006.01800.x"},{"key":"e_1_2_9_210_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00046"},{"key":"e_1_2_9_211_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.044784-0"},{"key":"e_1_2_9_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2013.05.012"},{"key":"e_1_2_9_213_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2771"},{"key":"e_1_2_9_214_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113508"},{"key":"e_1_2_9_215_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-020-00517-1"},{"key":"e_1_2_9_216_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1584801"},{"key":"e_1_2_9_217_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-013-1841-1"},{"key":"e_1_2_9_218_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1642-1"},{"key":"e_1_2_9_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2018.05.015"},{"key":"e_1_2_9_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.104502"},{"key":"e_1_2_9_221_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12268"},{"key":"e_1_2_9_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.12.025"},{"key":"e_1_2_9_223_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201701107"}],"container-title":["Reviews in Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.2232","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rmv.2232","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.2232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:52:20Z","timestamp":1693212740000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmv.2232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,31]]},"references-count":222,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1002\/rmv.2232"],"URL":"https:\/\/doi.org\/10.1002\/rmv.2232","archive":["Portico"],"relation":{},"ISSN":["1052-9276","1099-1654"],"issn-type":[{"value":"1052-9276","type":"print"},{"value":"1099-1654","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,31]]},"assertion":[{"value":"2020-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2232"}}