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It belongs to the family <jats:italic>Togaviridae<\/jats:italic> and genus <jats:italic>Alphavirus<\/jats:italic> and is an arthropod borne virus that transmits by the bite of an infected mosquito, mainly through <jats:italic>Aedes aegypti<\/jats:italic> and <jats:italic>Aedes albopcitus<\/jats:italic>. It is a spherical, enveloped virus with positive single stranded RNA genome. It was first discovered during 1952\u201053 in Tanganyika, after which outbreaks were documented in many regions of the world. CHIKV has two transmission cycles; an enzootic sylvatic cycle and an urban cycle. CHIKV genome contains 11,900 nucleotides and two open reading frames and shows great sequence variability. Molecular mechanisms of virus host\u2010cell interactions and the pathogenesis of disease are not fully understood. The disease involves three phases; acute, post\u2010acute and chronic with symptoms including high\u2010grade fever, arthralgia, macupapular rashes and headache. There is no licensed vaccine or specific treatment for CHIKV infection. This lack of specific interventions combined with difficulties in making a precise diagnosis together make the disease difficult to manage. In this review we aim to present the current knowledge of global epidemiology, transmission, structure, various aspects of diagnosis as well as highlight potential antiviral drugs and vaccines against CHIKV.<\/jats:p>","DOI":"10.1002\/rmv.2287","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T16:36:12Z","timestamp":1629822972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["The global emergence of Chikungunya infection: An integrated view"],"prefix":"10.1002","volume":"32","author":[{"given":"Khanzadi Nazneen","family":"Manzoor","sequence":"first","affiliation":[{"name":"Department of Biosciences COMSATS institute of Information Technology  Islamabad 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