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Despite their key roles, little attention has been given to the SOCS family as compared to other feedback regulators. To date, SOCS proteins have been found to be exploited by viruses such as herpes simplex virus (HSV), hepatitis B virus (HBV), hepatitis C virus (HCV), Zika virus, respiratory syncytial virus (RSV), Ebola virus, influenza A virus (IAV) and SARS\u2010CoV, just to name a few. The hijacking and subsequent upregulation of the SOCS proteins upon viral infection, suppress the associated JAK\u2010STAT signalling activities, thereby reducing the host antiviral response and promoting viral replication. Two SOCS protein family members, SOCS1 and SOCS3 are well\u2010studied and their roles in the JAK\u2010STAT signalling pathway are defined as attenuating interferon (IFN) signalling upon viral infection. The upregulation of SOCS protein by SARS\u2010CoV during the early stages of infection implies strong similarity with SARS\u2010CoV\u20102, given their closely related genomic organisation. Thus, this review aims to outline the plausibility of SOCS protein inhibitors as a potential therapeutic regimen for COVID\u201019 patients. We also discuss the antagonists against SOCS protein to offer an overview on the previous \u2018successes\u2019 of SOCS protein inhibition in various viral infections that may portray possible clues for COVID\u201019 disease management.<\/jats:p>","DOI":"10.1002\/rmv.2300","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T12:36:50Z","timestamp":1632227810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The Suppressor of Cytokine Signalling family of proteins and their potential impact on COVID\u201019 disease progression"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6213-6040","authenticated-orcid":false,"given":"Zheng Yao","family":"Low","sequence":"first","affiliation":[{"name":"School of Science Monash University  Bandar Sunway Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9532-8791","authenticated-orcid":false,"given":"Ashley Jia","family":"Wen Yip","sequence":"additional","affiliation":[{"name":"School of Science Monash University  Bandar Sunway Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2634-6213","authenticated-orcid":false,"given":"Vincent T. 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