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Most infected people are asymptomatic and do not show serious sequelae, while others may develop Epstein\u2010Barr virus (EBV)\u2010positive T and NK\u2010cell lymphoproliferations characterised by EBV\u2010infected T or NK cells. These disorders are more common in Asian and Latin American people, suggesting genetic predisposition as a contributing factor. The revised WHO classification classifies the lymphoproliferative diseases as: extranodal NK\/T\u2010cell lymphoma nasal type (ENKTL), aggressive NK\u2010cell leukemia (ANKL), primary EBV\u2010positive nodal T or NK cell lymphoma (NNKTL), systemic EBV\u2010positive T\u2010cell lymphoproliferative disease of childhood (STCLC), systemic chronic active EBV infection (sys CAEBV), hydroa\u2010vacciniforme (HV) and\u00a0severe mosquito bite allergy (SMBA). Recent advances in the molecular pathogenesis of these diseases have led to the development of new therapeutic strategies. Due to the infrequency of the diseases and broad clinicopathological overlap, the diagnosis and classification are challenging for both clinicians and pathologists. In this article, we aim to review the recent pathological findings which can be helpful for designing new drugs, clinical presentations and differential diagnoses, and suggested therapeutic interventions to provide a better understanding of these rare disorders.<\/jats:p>","DOI":"10.1002\/rmv.2328","type":"journal-article","created":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T02:59:31Z","timestamp":1644029971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["EBV associated T\u2010 and NK\u2010cell lymphoproliferative diseases: A comprehensive overview of clinical manifestations and novel therapeutic insights"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1941-4399","authenticated-orcid":false,"given":"Arman","family":"Shafiee","sequence":"first","affiliation":[{"name":"Student Research Committee Alborz University of Medical Sciences  Karaj 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